Excerpt: “…we are using the model system Caenorhabditis elegans. The genetic tools available in the nematode allow the mechanistic dissection of environmentally disrupted germline pathways as well as the comprehensive interrogation of our chemical environment for its effect on reproduction.”
My comment: Caenorhabditis elegans is one of the model organisms that I like to use to exemplify the fact that food odors and pheromones link the epigenetic landscape to the physical landscape of DNA in species from microbes to man.
Most people realize that germline maintenance is nutrient-dependent (from an environmental perspective). Unfortunately, some researchers do not realize that germline maintenance is pheromone-controlled. A significant contingent of researchers in the USA appear to think that mutations and natural selection contribute more to the evolution of biodiversity than nutrient-dependent pheromone-controlled ecological adaptations.
Watch as millions of dollars continued to be wasted on ridiculous ideas proposed by population geneticists as serious scientists who refuse to believe in pseudoscientific nonsense lead the way towards scientific progress by attacking scientific dogma.
“We show that these starvation-induced small RNAs are transmitted transgenerationally, providing a mean for starved worms to control the expression of relevant genes in consecutive generations.”
“Our principle aim in the lab is to attack scientific dogmas. Mainly, we aim to use powerful genetic tools to discover novel biological principles by which RNA affects formation and inheritance of complex traits.” That claim went missing from the Oded Rechavi lab web page in September 2014. Perhaps it drew unwanted attention to the lab. No matter, the short perspective: RNA and dynamic nuclear organization helped to clarify the fact that “…the interactions between pre-mRNA and proteins fine-tune alternative splicing in a manner that can gradually create new protein functionalities without the need to create additional genes and without affecting existing proteins [4-6].” Clearly, the focus on RNA-mediated events and amino acid substitutions that stabilize DNA in organized genomes will lead to a future in which no serious scientist reports results in terms of mutations, natural selection, and the evolution of biodiversity.
Excerpt: “The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding behaviours of P. pacificus and C. elegans“, Ralf Sommer concludes. A clear-cut result like that was not what he had necessarily expected.
My comment: Some researchers do not expect the obvious connection from nutrient uptake to pheromone-controlled ecological speciation to show up in the neurogenic niche construction of nematodes, which links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species with neuronal networks that obviously contain differentiated cell types. The fact that cell type differentiation occurs via the conserved molecular mechanisms of cell type differentiation in species from microbes to man seems to have escaped their attention.