Transgenerational germline maintenance

Studying Germline Maintenance from an Environmental Perspective


Excerpt: “…we are using the model system Caenorhabditis elegans. The genetic tools available in the nematode allow the mechanistic dissection of environmentally disrupted germline pathways as well as the comprehensive interrogation of our chemical environment for its effect on reproduction.”

My comment: Caenorhabditis elegans is one of the model organisms that I like to use to exemplify the fact that food odors and pheromones link the epigenetic landscape to the physical landscape of DNA in species from microbes to man.

Most people realize that germline maintenance is nutrient-dependent (from an environmental perspective). Unfortunately, some researchers do not realize that germline maintenance is pheromone-controlled. A significant contingent of researchers in the USA appear to think that mutations and natural selection contribute more to the evolution of biodiversity than nutrient-dependent pheromone-controlled ecological adaptations.

Watch as millions of dollars continued to be wasted on ridiculous ideas proposed by population geneticists as serious scientists who refuse to believe in pseudoscientific nonsense lead the way towards scientific progress by attacking scientific dogma.

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

“We show that these starvation-induced small RNAs are transmitted transgenerationally, providing a mean for starved worms to control the expression of relevant genes in consecutive generations.”

“Our principle aim in the lab is to attack scientific dogmas. Mainly, we aim to use powerful genetic tools to discover novel biological principles by which RNA affects formation and inheritance of complex traits.” That claim went missing from the Oded Rechavi lab web page in September 2014. Perhaps it drew unwanted attention to the lab. No matter, the short perspective: RNA and dynamic nuclear organization helped to clarify the fact that “…the interactions between pre-mRNA and proteins fine-tune alternative splicing in a manner that can gradually create new protein functionalities without the need to create additional genes and without affecting existing proteins [4-6].” Clearly, the focus on RNA-mediated events and amino acid substitutions that stabilize DNA in organized genomes will lead to a future in which no serious scientist reports results in terms of mutations, natural selection, and the evolution of biodiversity.

See also:

System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes

reported as:

The neurobiological consequence of predating or grazing

Excerpt: “The patterns of synaptic connections perfectly mirror the fundamental differences in the feeding of P. pacificus and C. elegans“, Ralf Sommer concludes. A clear-cut result like that was not what he had necessarily expected.

My comment: Some researchers do not expect the obvious connection from nutrient uptake to pheromone-controlled ecological speciation to show up in the neurogenic niche construction of nematodes, which links the epigenetic landscape to the physical landscape of DNA in the organized genomes of species with neuronal networks that obviously contain differentiated cell types. The fact that cell type differentiation occurs via the conserved molecular mechanisms of cell type differentiation in species from microbes to man seems to have escaped their attention.



About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society