Transgenerational biological embedding / imprinting in gametes

Transgenerational biological embedding / imprinting in mammalian male gametes appears to link the conserved molecular mechanisms of speciation in species from microbes to man to subtle differences in Skull 5.

For example, in my model, subtle alterations in the nutrient-dependent thermodynamics of intercellular signaling and stochastic gene expression enable the morphological adaptations across species that include differences in Skull 5. See my comments to the Science Magazine site on the Skull 5 article.

Transgenerational epigenetic effects on these alterations must extend to organism-level thermoregulation to affect species diversity.

In a report published earlier this year, the diversity I attribute to thermodynamics and organism-level thermoregulation appears to originate in male gametes of mice.

Receptors involved in sugar and amino acid sensing in taste cells and in the gastrointestinal tract are also expressed in testis and sperm. The genetic absence of these receptors leads to male-specific sterility in a mammal. However, in the experiment, sterility was quickly reversed after clofibrate was removed from the diet. See: Mosinger et al (2013).

This may be the clearest indicator of how the nutrient-dependent molecular epigenetics of alternative splicings link the epigenetic ‘landscape’ to the physical landscape of DNA. The link now appears to include transgenerational epigenetic effects of diet on the de novo creation of “taste” and “smell” receptors in male gametes.

Predictably, this extends what we detailed in our 1996 Hormones and Behavior review article: “From fertilization to adult sexual behavior” from epigenetic effects in yeast to transgenerational epigenetic effects of olfactory/pheromonal input that alter 1) the physiology of nutrient-dependent pheromone-controlled reproduction, 2) morphological changes in the brain and body, which include skull morphology, and 3)the behavior of a single Homo species (sans mutation-initiated natural selection).

I do not think effects of a “mutation” in a single base pair (suggested elsewhere by David Marjanović) can be compared to epigenetic cause and effect across species. Thus, suggestions that the differences in skull morphology are somehow associated with a “mutation” in a base pair, instead of nutrient-dependent pheromone-controlled changes in a base pair (i.e., biological embedding) should be supported with experimental evidence.

Meanwhile, given the lack of information that might otherwise support mutation-driven evolution, which seems more likely:

1) Mutations in base pairs alter the hydrogen bonds that link sensory input to ecological, social, neurogenic, and socio-cognitive niche construction as is required for adaptive evolution to occur in species from microbes to man.

2) Nutrient uptake and cellular metabolism and organism-wide metabolism of nutrients to species-specific pheromones in unicellular and multicellular organisms control alterations in hydrogen bonds via the nutrient-dependent pheromone-controlled physiology of reproduction in species from microbes to man.

In my model, the nutrient-dependent pheromone-controlled substitution of  the achiral amino acid glycine in the gonadotropin releasing hormone (GnRH) molecule, which is conserved across what appears to be 400 million years of adaptive evolution, appears to link physics and biology. Is there an evolutionary theory that suggests that link is due to mutations in base pairs?


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society