The thrill is gone; how to get it back

Why the thrill is gone: Scientists identify potential target for treating major system of depression


JULY 11, 2012

Excerpt: “This hormone, melanocortin, signals to an ancient and almost universal apparatus deep in the brain called the reward circuit, which has evolved to guide animals toward resources, behaviors and environments — such as food, sex and warmth — that enhance their prospects for survival.”

My comment to the medicalxpress site:

The study design and results attest to the efficacy of incorporating the perspective provided in the FDA Critical Path Initiative (for development of therapeutic drugs). Finally, someone else looks at the gene, cell, tissue, organ, organ system pathway that links sensory input to hormones and their effects on behavior.

How could they have missed the more obvious connection to the interaction among the gonadotropin releasing hormone (GnRH)neuronal system, luteinizing hormone, and melanocortin?

This is but one of many studies that link the epigenetic effects of nutrient chemicals and pheromones to adaptive evolution via classically conditioned behaviors directly linked from olfactory/pheromonal input to brain development and plasticity altered by stress. One need only look at how glucose alters hypothalamic GnRH pulse frequency to be clued in to how nutrient chemicals, stress, and social encounters regulate neuroendocrine and neuroimmune system function — with melanocortin CORRELATES.

My comments to the psychiatry-research yahoo group: If you read the article and it is not clear why I have attempted to differentiate between Glen Sizemore’s ridiculous approach to potentially effective treatment regimens, and the required biologically based approach, you should abandon hope of ever understanding the foundations of all behavior.

It’s not training, as I think Glen would still like you to believe. If you understand nothing else about this study, it should still be clear that behavior is receptor-mediated, and that no “training receptors” were considered in the study design.  That means the behaviorists can now close up shop and attempt to find productive work, perhaps as lab assistants in facilities that research biologically based behavior.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society