The same neural mechanisms are at work in worms and humans

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Perspective Neuroscience The Mood of a Worm by Scott W. Emmons

Science 26 October 2012: 475-476.

Excerpt:  “On pages 540 and 543 in this issue, Garrison et al. (1) and Beets et al. (2), respectively, add to a growing body of evidence that even at the highest levels of coordinating fundamental and complex behaviors, the same neural mechanisms are at work in worms and humans. ”

My comment: The yeast mating pheromone activates mammalian gonadotrophs and there are downstream effects on luteinizing hormone (LH) of a similar molecule called gonadotropin releasing hormone (GnRH), which is conserved across approximately 400 million years of vertebrate evolution. GnRH is also essential to both HPG axis and HPA axis regulation. This suggests that the epigenetic effects of nutrient chemicals and species-specific pheromones on the control of adaptive evolution by GnRH precede any effect of hormones like oxytocin or vasopressin on the development of mammalian behavior.

So far as I know, a molecule similar to GnRH is essential to nutrient chemical-dependent and pheromone-controlled reproduction in all species, including C. elegans. If oxytocin and vasopressin are equally important to adaptive evolution, can we anticipate that their secretion is also directly effected by nutrient chemicals or pheromones. If not, they must play a decidedly reduced role in adaptive evolution of social and sexual behaviors in species from worms to mammals. Indeed, the role of GnRH can be linked via olfaction and odor receptors to a clear evolutionary trail that can be followed from unicellular organisms to insects to humans — one that is exemplified in the honeybee model organism. Given any consideration for adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction, it is difficult for me to conceive of any crucial role for oxytocin and vasopressin
except as secondary to the role of GnRH and its receptor diversification.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society