The neuroscience of adaptive evolution

Neuroscience: As the worm turns

“With the help of a tiny worm, Cornelia Bargmann is unpicking the neural circuits that drive eating, socializing and sex.”

by Stephen S. Hall

Excerpt: “…these deaf, part-blind, transparent creatures, which resemble nothing so much as wriggling specks of lint, could nonetheless yield enormous insight into how a nervous system creates behaviour.”

My comment:

James Vaughn Kohl said:

Adaptive evolution appears to be nutrient-dependent and pheromone-controlled in species from microbes to man. This was demonstrated by Bumbarger et al (2013) in the context of: “System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes.” Their approach incorporates aspects of ecological, social, and neurogenic niche construction elucidated by Cori Bargmann et al throughout her career, and in the honeybee model organism throughout the careers of many others. The three stages of niche construction are required to link sensory input to de novo protein synthesis (to genes) and to neurogenetically programmed behavior that enables social selection (for nutrient-dependent pheromone production).

Pheromones control genetically predisposed species-specific behavioral development via the control of nutrient-dependent reproduction in asexual and sexual variants of all species. The theme involves the epigenetic tweaking of immense gene networks by nutrients with control of the “tweaking” by pheromones, presumably via adaptive changes in the microRNA/messenger RNA balance.

Can we expect that a change in the diet of C. elegans would result in epigenetic tweaking manifested in the neurocircuitry of their sexual selection? If so, the results would go a long way towards explaining how an alanine substitution appears to alter the thermodynamics of intranuclear interactions, protein biosynthesis, and the adaptive evolution of nutrient-dependent physical traits associated with immune system function and with glandular secretions trapped by hair that contribute to pheromone production and distribution in a human population — as recently reported by Kamberov et al (2013) Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant and in Grossman et al (2013) Identifying Recent Adaptations in Large-Scale Genomic Data.

Declared commercial interest: I own the domain and have modeled Nutrient-dependent Pheromone-controlled reproduction in a series of published and unpublished works.

See also: Lucrative Prize for Life Scientists: Excerpt: This year’s recipients, who are free to use the money as they please, include Cornelia Bargmann, who investigates neural circuits and animal behavior at Rockefeller University…”

My comment: Congratulations, Cori!

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society