The Missing Transgenerational Epigenetic Links

Lamarck and the Missing Lnc

Epigenetic changes accrued over an organism’s lifetime may leave a permanent heritable mark on the genome, through the help of long noncoding RNAs.

By Kevin V. Morris | October 1, 2012

Excerpt: “In one study carried out in mice, an environmental stress that resulted in aggressive behavior in males caused the same behavior in their offspring.”

Excerpt: “…. epigenetics, rather than random genetic point mutations, could provide the missing link between environmental pressure and the resulting genetic variability that generates robustness of a species.

Most certainly, if such a pathway were to exist in human cells, one would expect it to be elusive purely due to the sheer complexity of the process—involving lncRNAs, epigenetic changes, DNA methylation, and deamination. Thus, it is not out of the realm of possibility that such a mechanism exists, but has yet to be elucidated by science.


My comment: I’m a medical labortory scientist. What did I fail to scientifically elucidate?

In an article published earlier this year, I detailed how an environmental drive evolved from that of nutrient chemical ingestion in unicellular organisms to that of socialization in insects. Using the honeybee model organism as an example, the article also makes it clear that food odors and pheromones cause changes in hormones, which also have developmental affects on behavior in nutrient-dependent, reproductively fit individuals across species of vertebrates.

It is the epigenetic effects of nutrient chemicals and pheromones on intracellular signaling, on stochastic gene expression, and on genetically predisposed behavior that enable transgenerational epigenetic inheritance in species from microbes to man.  There are now hints in the literature (as indicated in the excerpt above) that transgenerational epigenetic effects on behavior are receiving the consideration that is due. But the idea that there are transgenerational epigenetic effects on behavior has already been substantiated by complete experimental evidence from every species that requires nutrient chemicals for individual survival and pheromones to control reproduction. How many species is that? All of them!

I wrote: “The concept that is extended is the epigenetic tweaking of immense gene networks in ‘superorganisms’ (Lockett, Kucharski, & Maleszka, 2012) that ‘solve problems through the exchange and the selective cancellation and modification of signals (Bear, 2004, p. 330)’. Those immense gene networks enable epigenetic effects of nutrient chemicals and pheromones on stochastic gene expression, which lead to species-specific changes in behavior via transgenerational epigenetic inheritance.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338. DOI: 10.3402/snp.v2i0.17338.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society