The genetics myth meets the great pheromone myth

The genetics myth:  Clip from Zeitgeist 3: Moving forward. (13.57 minute video) Several prominent neuroscientists discuss epigenetic effects of the environment that are being brought to bear as we learn more about genetically predisposed behaviors, mental disorders, and physical disorders.

Exemplified, albeit without mention, in this next link is the latest information on the likely epigenetic effects of glucose in Alzheimer’s disease and in ALS. Researchers uncover toxic interaction in neurons that leads to dementia and ALS December 10, 2012 in Medical research

Excerpt: By improving the scientific community’s understanding of the biological processes leading to frontotemporal dementia, the researchers have also paved the way for the development of new therapies to prevent or combat the disease, says Leonard Petrucelli, Ph.D., chair of the Department of Neuroscience at Mayo Clinic in Florida, who led the research.

My comment: TDP-43 facilitates the production of a subset of precursor  microRNAs (miRNAs). It’s involvement in miRNA biogenesis is indispensable for neuronal outgrowth. Glucose is indispensable for neuronal survival. If TDP-43 alters the glucose-dependent miRNA / messenger RNA balance that helps to ensure intracellular homeostasis in gonadotropin releasing hormone neurosecretory neurons of mammalian brain tissue, the results reported today on TDP-43 and Alzheimer’s support a  broad-based approach to the study of glucose and post-transcriptional regulation of miRNA expression in both the nucleus and the cytoplasm.

The involvement of progranulin in hypothalamic glucose-sensing and the involvement of TDP-43 in dysregulation of progranulin, which protects against cell death associated with disease, suggests to me that what ALS and dementia have in common with other neurodegenerative diseases is that they are all linked to the microRNA / messenger RNA balance. This links epigenetic effects of nutrient chemicals and pheromones to intracellular signaling and to non-random stochastic gene expression via intermolecular changes in DNA that enable de novo gene creation of olfactory receptor genes. Altered creation and  expression of olfactory receptor genes could thereby explain, at least in part, deficits in olfactory acuity and specificity associated with neurodegenerative diseases at the cellular level of the 4.5 million DNA switches in the human genome.

I mention this only to note that random mutations are not likely to be driving disease processes — like Alzheimer’s, and that proper nutrition and pheromone therapy offers hope to an aging population.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society