The end of random mutations theory

Toward a combinatorial nature of microRNA regulation in human cells

Ohad Balaga, Yitzhak Friedman, Michal Linial

Nucl. Acids Res. (2012) 40(19): 9404-9416

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Excerpt: “Systems biology has identified small miRNA modules that by simultaneous regulation alter a functional module (e.g. EGFR-driven cell-cycle pathway (65)). The hierarchy among miRNAs suggests that some miRNAs act as pathway hubs whereas others are interconnected with transcription factors to provide small functional modules (60).”

My comment: If evolutionary theorists could explain how modulation of mRNA executed in a combinatorial fashion can yield a substantial change in cell phenotype  via control of mRNA and stochastic gene expression by miRNA, they could use the unknown natural mechanisms that might be causal to the change in stochastic gene expression in a logico-/psycho universe to get from one cell type to another type (e.g., from a skin cell to a hormone-secreting cell in the human brain). An under-informed theorist or buffoon could then try to explain how different cell types in different species evolved due to random mutations that somehow enabled our adaptively evolved brain-directed hormone-controlled behaviors.

As an alternative, evolutionary theorists and buffoons could simply accept the facts.

The epigenetic effects of nutrient chemicals calibrate the molecular mechanisms of stochastic gene expression, which is required for individual survival, and the metabolism of nutrient chemicals epigenetically controls species survival via pheromones and the molecular mechanisms of reproduction. Succinctly put, the concept that is extended is the epigenetic tweaking of immense gene networks in superorganisms that solve problems through the exchange and the selective cancellation and modification of signals (as occurs via miRNA and mRNA interactions).

Of course, this means that olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans. But by now most people should already know that and they should also be closer to thinking in terms of adaptive evolution via ecological, social, neurogenic, and socio-cognitive niche construction, which makes sense. Most people should not still be thinking that random mutations cause adaptive evolution. Instead, they should be telling others how ridiculous that theory was.

Thank you for doing your part to advance scientific knowledge and dispense with ridiculous theories.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society