Targeting a cancer gene

November 20, 2013 James V. Kohl 0

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the […]

No Image

Evolution at work sans random mutations

November 10, 2012 James V. Kohl 0

In my model, the phrase “from microbes to man” refers specifically to this yeast species, Saccharomyces cerevisiae (i.e., a microbe) where nutrient chemicals determine not only sexual orientation but also sexually dimorphic pheromone production

No Image

Modeling odor processing in microbes, mice, and mankind

March 27, 2012 James V. Kohl 0

Whether it is called tuning, calibration, control, or standardization, the direct effect of chemical stimuli on intracellular signaling and gene expression occurs as other sensory input is processed. Simply put, cause and effect are directly linked to chemical stimuli and gene expression at the same time other sensory input is processed.