“… the “mutational vicinity” is probably found in the molecular vicinity of a “metabolic niche”.
The epigenetic effects are on interactions among all the other neuronal systems and hormone secretion that interact with the GnRH neuronal system, which is central to all developmental differences in the brain of males and females.
Integrating the chemical ecology of the social brain’s adaptive evolution allows it to be viewed – along with adaptive evolution of the CNS – at four levels of niche construction: 1) ecological, 2) social, 3) neurogenic, and 4) socio-cognitive.
No neurogenic niche does not mean no behavior, and no socio-cognitive niche only means that the unconscious affects of sensory stimuli on hormones and behavior will predominate.
With construction of our socio-cognitive niche comes free will.
The problem with multi-level selection in humans seems likely to be one that is due to ignorance about the role of pheromones in the context of ecological, social, neurogenic, and socio-cognitive niche construction.
My idea is that nutrient chemical-dependent ecological niche construction and pheromone-dependent social niche construction contribute equally to the neurogenic niche construction that is responsible for adaptive evolution, development of the mammalian brain, and construction of our socio-cognitive niche.
GnRH also links nutrient chemicals and pheromones directly to adaptive evolution via the required ecological, social, neurogenic, and cognitive niche construction evidenced by the apparent design in biology.
What surprises me is that anyone would dispute the significance of modeling behavioral development across the ecological, social, neurogenic, and cognitive niche construction domains by incorporating the epigenetic effects of nutrient chemicals and pheromones on intracellular signaling and stochastic gene expression.