Stress and controlled proliferation

Temperature-Dependent Immunity

Scientists show that mice housed at room temperature are less able to fight tumors.

By Abby Olena | November 18, 2013

Excerpt:  “It’s one of the things that’s under everybody’s nose, and nobody really thought about it much,” said Mark Dewhirst, a professor of radiation oncology and pathology at Duke University in North Carolina, who was not involved in the work. “Everybody thought that mice would be fine at room temperature, but nobody ever thought to look,” he continued. That the authors demonstrate “quite profound effects on antitumor immunity is really pretty remarkable,” Dewhirst added. “This is quite a tour de force.”

My comment: Here’s an outdated paradigm that is literally under everybody’s noses: Antibiotic resistance (a function of the innate immune system) is typically selected by the presence of the antibiotic.

No paradigm shift has occurred despite what is known about the link from physics to chemistry via thermal stress associated with nutrient stress during adaptations to the epigenetic “landscape” in species from microbes to man. How do organisms adapt?

Alternative splicings link the epigenetic  landscape to the physical landscape of DNA in organized genomes. The alternative splicings clearly show that the adaptations are nutrient-dependent and pheromone-controlled. However, the nutrient-dependent pheromone-controlled adaptations are typically attributed to thermal stress and mutations. For example, this mistaken attribution occurs even in the context of exhibited resistance to rifampicin in E. coli that is clearly nutrient-dependent since a fitness advantage results within the context of a thermal stress/low glucose environment.

The molecular mechanisms of alternative splicings do not change across species. Nutrient stress is thermal stress and social stress is thermal stress, which is how why both nutrient stress and social stress can be linked to cancer and its progression. We should probably link nutrient stress and social stress to cancer treatment before running off half-cocked again as if we didn’t know about differences in temperature-controlled growth characteristics of other organisms (i.e., all of them) that link stress to their nutrient-dependent morphology and pheromone-controlled proliferation.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society