Stem cell memory is biophysically constrained (2)

If stem cell memory is biophysically constrained, by nutrient-dependent pheromone-controlled amino acid substitutions, we can expect to find experimental evidence that conserved molecular mechanisms link the basic principles of nucleosome retention in plants to nucleosome retention in mouse and human sperm. That finding would support a model of epigenetic inheritance by nucleosomes between generations, across kingdoms and across species.

For example, if retention of histones during sperm cell development was linked to retention of histones and epigenetic inheritance between generations in plants and  mice, the role of histone methylation might be deemed to exemplify how nutrient-dependent amino acid substitutions in plants contribute to species diversity in mammals. See, for instance: Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa

The question arises: Could the following sequence be linked from plants to mammals via nutrients in the soil? In animals, for example,

1) Vitamin-induced base pair “flipping” results in…

Similarly, the addition of a phosphate group to a histone triggered the entire nucleosome to change shape. If the change in the shape of the nucleosome led to

2) amino acid substitutions that… epigenetically effected the protein folding we could expect to find evidence that amino acid substitutions

3) stabilize the intracellular thermodynamic interactions required for…

4) protein folding, which result in…

5) nutrient-dependent de novo creation of cell types and…

6) maintenance of their diversity via the… a single amino acid difference in the structure of a histone that enables it to serve as a kind of memory device for the cell. Cell memory could be maintained via…

7) pheromone-controlled physiology of reproduction, which is responsible for…

8) ecological adaptations manifested in…

9) morphological phenotypes and in…

10) behavioral phenotypes.

The addition of a phosphate group to a histone triggered the entire nucleosome to change shape

Thus, ecological variation and ecological adaptations are manifested in vitamin-dependent morphological and behavioral phenotypes, which are associated with micronutrient- and macronutrient-dependent species diversity.

 

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society