If stem cell memory is biophysically constrained, by nutrient-dependent pheromone-controlled amino acid substitutions, we can expect to find experimental evidence that conserved molecular mechanisms link the basic principles of nucleosome retention in plants to nucleosome retention in mouse and human sperm. That finding would support a model of epigenetic inheritance by nucleosomes between generations, across kingdoms and across species.
For example, if retention of histones during sperm cell development was linked to retention of histones and epigenetic inheritance between generations in plants and mice, the role of histone methylation might be deemed to exemplify how nutrient-dependent amino acid substitutions in plants contribute to species diversity in mammals. See, for instance: Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa
The question arises: Could the following sequence be linked from plants to mammals via nutrients in the soil? In animals, for example,
1) Vitamin-induced base pair “flipping” results in…
Similarly, the addition of a phosphate group to a histone triggered the entire nucleosome to change shape. If the change in the shape of the nucleosome led to
2) amino acid substitutions that… epigenetically effected the protein folding we could expect to find evidence that amino acid substitutions
3) stabilize the intracellular thermodynamic interactions required for…
4) protein folding, which result in…
5) nutrient-dependent de novo creation of cell types and…
6) maintenance of their diversity via the… a single amino acid difference in the structure of a histone that enables it to serve as a kind of memory device for the cell. Cell memory could be maintained via…
7) pheromone-controlled physiology of reproduction, which is responsible for…
8) ecological adaptations manifested in…
9) morphological phenotypes and in…
10) behavioral phenotypes.
The addition of a phosphate group to a histone triggered the entire nucleosome to change shape
Thus, ecological variation and ecological adaptations are manifested in vitamin-dependent morphological and behavioral phenotypes, which are associated with micronutrient- and macronutrient-dependent species diversity.
