Seemingly futile cycles are not thermodynamically futile

Scientists discover an on/off switch for aging cells

The switch controls the growth of telomeres, the timekeepers of cells

Excerpt: Understanding how this “off” switch can be manipulated–thereby slowing down the telomere shortening process–could lead to treatments for diseases of aging (for example, regenerating vital organs later in life).”

My comment: Seemingly futile thermodynamic cycles of protein biosynthesis and  degradation appear to be confusing. I’m somewhat certain that the folks at Salk realize that cycles of biophysically-constrained nutrient-dependent RNA-mediated protein folding limit how the switches are epigenetically-effected by olfactory/pheromonal input. I’m unsure that what they know is being conveyed to others.

This news report says nothing about how the conserved molecular mechanisms of nutrient-dependent, RNA-mediated, pheromone-controlled cell type differentiation via amino acid substitutions differentiates cell types in species from microbes to man during their life-cycle transitions.See for example:

The journal article is behind a paywall. I have requested it from the corresponding author and may be able to link “Regulated assembly and disassembly of the yeast telomerase quaternary complex” to the thermodynamics of protein structure and function from what they say about “The balance between the assembly and disassembly pathways, which dictate the levels of the active holoenzyme in the cell…” and homeostasis. Obviously, homeostasis is manifested in organism-level thermoregulation.

Hopefully, I can match what is known about biophysical constraints on light-induced amino acid substitutions to nutrient-induced amino acid substitutions in plants and animals via Single-residue insertion switches the quaternary structure and exciton states of cryptophyte light-harvesting proteins. The rest of the story can then be compared to the ‘Just-So’ stories of evolutionary theorists who left physics and chemistry out of their ridiculous theories based on population genetics.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society