RNA-mediated species specificity


Scientists uncover striking differences between mouse and human gene expression across a variety of tissues.

By Jyoti Madhusoodanan | November 17, 2014

Excerpt: “…results published today (November 17) in PNAS reveal widespread differences between human and mouse gene expression, both in protein-coding and noncoding genes, suggesting that understanding these disparities could help explain fundamental differences in the two species’ physiology.”

My comment:  See also: Physiology is rocking the foundations of evolutionary biology 

Conclusion: “Perhaps the elegant mathematics and the extraordinary reputation of the scientists involved blinded us to what now seems obvious; the organism should never have been relegated to the role of mere carrier of its genes.”

My comment to The Scientist Magazine:

(This model of RNA-mediated cell type differentiation was first presented in our 1996 Hormones and Behavior review.)

The metabolism of nutrients to species-specific pheromones that control the physiology of reproduction in species from microbes to man exemplifies how comparisons of RNA-mediated transcriptional landscapes have since established the validity of Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

“Until recently, the association of the nutrient choline in humans and its metabolism to trimethylamine odor in different species of mice was the best example of how a change in diet becomes associated with the presence of mammalian conspecifics whose androgen estrogen ratio-associated odor distinguishes them sexually, and also as nutrient-dependent physically fit mates (Stensmyr & Maderspacher, 2013). The mouse model makes it clearer that glucose uptake changes cellular thermodynamic equilibrium and differential pathway regulation that results in adaptively evolved fitness in species from microbes (Kondrashov, 2012) to mammals. Species-specific health and reproductive fitness is associated with nutrient-dependent amino acid substitutions and with pheromone-controlled reproduction. Disease is associated with mutations exemplified in cancer where perturbations of the glucose-dependent thermodynamic/thermoregulatory equilibrium are equally clear (Locasale, 2012).

Theorists insist that beneficial mutations somehow lead to increasing organismal complexity manifested in epigenetically altered transcriptional landscapes. Their theories are based on what they learned about conserved molecular mechanisms from population geneticists, which serious scientists now understand is NOTHING AT ALL.

The serious scientists have learned from comparisons of transcriptional landscapes across species and comparisons of morphological AND behavioral phenotypes. See for example, Dobzhansky (1973):

…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.

Theorists are now forced to claim that amino acid substitutions are akin to mutations. But mutations perturb the chemistry of protein folding, which is why they cannot lead to increasing organismal complexity.

For comparison, amino acid substitutions are linked from the de novo creation of olfactory receptor genes to species diversity in vertebrates and invertebrates via conserved molecular mechanisms of ecological, social, neurogenic, and socio-cognitive niche construction — with examples in my 2013 review.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society