RNA-mediated species diversification from microbes to primates

Mycobacteriophage-drived diversification of Mycobacterium abscessus Biology Direct (15 September 2014) OPEN ACCESS

Excerpt (with my emphasis): “Widespread occurrence of phage sequences in almost all studied M. abscessus complex isolates suggests that the rate of prophage invasion is faster than the rate of mutation, implying rapid evolution of M. abscessus.”

My comment: The faster rate of prophase invasion suggests ecological adaptations occur more rapidly than evolution. That may be why no experimental evidence of biologically-based cause and effect suggests that evolution of biodiversity somehow occurs via mutations and natural selection; the processes are too slow to be linked to extant ecologically-adapted biodiversity. Also, the Wikipedia summary (below) does not support ideas about the evolution of biodiversity. It supports the concept of chemically-induced RNA-mediated events that can now be linked from nutrient-dependent chromosomal rearrangements in microbes (e.g., Mycobacterium spp.) to explanations of RNA-mediated species diversity in primates via conserved molecular mechanisms.

RNA-mediated events link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. See Kohl (2013) for review.

For example, UV light-induced amino acid substitutions in plants and nutrient-dependent amino acid substitutions in animals are biophysically constrained, which suggests that the role of RNA-mediated events and amino acid substitutions in cell type differentiation extends from viruses to primates in the context of thermodynamic cycles of protein biosynthesis and degradation that lead to more efficient organism-level thermoregulation via the Laws of Physics.


Wikipedia: “A prophage is a bacteriophage (often shortened to “phage”) genome inserted and integrated into the circular bacterial DNA chromosome or existing as an extrachromosomal plasmid. This is a latent form of a phage, in which the viral genes are present in the bacterium without causing disruption of the bacterial cell.

Upon detection of host cell damage, such as UV light or certain chemicals, the prophage is excised from the bacterial chromosome in a process called prophage induction. After induction, viral replication begins via the Lytic Cycle. In the lytic cycle, the virus commandeers the cell’s reproductive machinery. The cell may fill with new viruses until it lyses or bursts, or it may release the new viruses one at a time in a reverse endocytotic process. The period from infection to lysis is termed the latent period. A virus following a lytic cycle is called a virulent virus. Prophages are important agents of horizontal gene transfer, and are considered part of the mobilome. All families of bacterial viruses with circular (single-stranded or double-stranded) DNA genomes or replicating their genomes through a circular intermediate (e.g., Caudovirales) have temperate members.[1]


Addendum: “… the synergistic use of tissue diagnostic techniques and microbiology is paramount to render an accurate diagnosis.” (Patel, Rhodes, Spicknall, & Mortensen, 2014)

That fact cannot be ignored if medical practitioners are ever able to escape the ignorance touted by theorists and their ridiculous ideas about mutations, natural selection, and the evolution of biodiversity. We no longer have the option to believe in pseudoscientic nonsense and must begin to treat diseases and disorders in the context of what they are: failed ecological adaptation. See also: Combating Evolution to Fight Disease and RNA and dynamic nuclear organization.


Patel, R., Rhodes, J., Spicknall, K. E., & Mortensen, J. (2014). Case Twenty NIne: The synergistic role of microbiology and pathology. Journal of Continuing Education Topics & Issues, 16(3), 88-92.


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society