RNA-mediated genetic engineering (Part 3)

RCas9: A programmable RNA editing tool

Excerpt: “The researchers envision a wide range of potential applications for RCas9. For example, an RCas9 tethered to a protein translation initiation factor and targeted to a specific mRNA could essentially act as a designer translation factor to “up-” or “down-” regulate protein synthesis from that mRNA.”

My comment: This “up-” or “down-” regulation of protein synthesis from mRNA occurs naturally in the context of RNA-mediated genetic engineering. Nutrient uptake alters the microRNA/messenger RNA balance and thermodynamic cycles of DNA methylation, protein biosynthesis, and degradation. Protein biosynthesis and degradation are stabilized by nutrient-dependent amino acid substitutions that differentiate all cell types of all individuals of all species.

It is important to again note that RNA molecules function as the central conduit of information transfer in biology. Moving forward, that fact will limit the pseudoscientific nonsense that evoltionary theorists have continued to tout. Clearly, DNA is not the central conduit of information transfer in biology, and information transfer is essential to ecological adaptations. If information about the epigenetic landscape does not lead to accurate representations of cause and effect via RNA-mediated changes to the physical landscape of DNA in organized genomes, ecological variation cannot lead to ecological adaptations manifested in the morphological and behavioral phenotypes of species from microbes to man. Instead, DNA mutations would lead to the evolution of biodiversity and no known molecular mechanisms allow that to happen.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society