At the 2012 Meeting I learned that the microRNA/messenger RNA balance had emerged during the past decade to be the most likely regulator of all downstream effects on cell type differentiation. That inspired me to focus on what I knew about RNA-mediated events and put what we detailed about them in our 1996 Hormones and Behavior review into the context of a this model.
Additional examples of nutrient-dependent pheromone-controlled cell type differentiation will be presented at the 2014 meeting. The link from nutrient-dependent RNA-directed DNA methylation to epigenetic effects on cell type differentiation and behavior becomes clearer in these selected presentations.
Additional search strategies include
Also, place your search strategy on GnRH into the context of Feedback loops link odor and pheromone signaling with reproduction For example: “Indications that GnRH peptide plays an important role in the control of sexual behaviors suggest that pheromone effects on these behaviors might also involve GnRH neurons.” p 683.
The link from pheromones to epigenetically effected hormones that affect hormone-organized and hormone activated behavior is represented in the abstract linked here: RNA-sequencing after translating ribosomal affinity purification (TRAP) identifies in vivo gene expression differences in CA3 neurons of mice subjected to early life stress (ELS)
Here is an abstract excerpt that appears to our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior, and its representations of RNA-mediated sex differences in cell types to the presentations on RNA-directed DNA methylation, and RNA-mediated events that link amino acid substitutions to species-specific sex differences in behavior:
Epigenetic modifications to the DNA imprint early life environment and experience onto the genome. Emerging evidence suggests the default female pattern involves epigenetic repression of the male genome which is emancipated by gonadal steroid inhibition of DNMT activity and subsequent demethylation of key genes, allowing for their expression.