Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs

Of Cells and Limits

Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement.

By Anna Azvolinsky | March 1, 2015


The rejection letter came from Francis Peyton Rous who received the Nobel Prize a few years later for his discovery of chicken tumor viruses.

My comment:

My 2014 invited review of nutritional epigenetics detailed how differences in the microRNA/messenger RNA balance link viral microRNAs from ecological variation to ecological adaptations via the RNA-mediated differentiation of all cell types in all individuals of all species. It was returned without review.

The problem appears to be the clear link from viruses to RNA-mediated cell type differentiation via amino acid substitutions that stabilize DNA in the organized genomes of all species. That clear link led to the invitation to submit the review.

The invitation came after publication of  Nutrient-dependent/pheromone-controlled adaptive evolution: a model and a series of other previously published works that detail the molecular epigenetics of biophysically constrained RNA-mediated protein folding.

Many of my “peers” still seem to think that mutations lead to the evolution of biodiversity. They won’t consider the fact that viral microRNAS cause entropy or that nutrient-dependent microRNAs link entropic elasticity from DNA repair to the physiology of reproduction.

That anti-entropic fact links the metabolism of nutrients to species-specific pheromones that control the physiology of reproduction. The pheromones link RNA-mediated fixation of nutrient-dependent amino acid substitutions from metabolic networks to genetic networks in species from microbes to humans. See for examples in humans: Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing.

Examples from more than 14,000 patients now show what serious scientists have learned during the past two decades. What they have learned is exemplified in the honeybee model organism and many other model organisms.

In 2013, I wrote: “The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of the X chromosome, learning and memory, as well as conditioned responses to sensory stimuli (Kohl, 2012).”

In his 2003 presentation to the American Philosophical Society, Greg Bear told others about ancient viruses in the human genome that link sexual recombination and pheromonal interaction in multicellular organisms. The organisms communicate with each other, which links what is currently known about physics, chemistry, and molecular epigenetics to species-wide epigenesis and to the obvious anti-entropic examples of epistasis via metabolic and genetic networks.

Unfortunately, more than a decade after Greg Bear presented the facts about biodiversity in two of his science fiction novels, the accuracy of his claims about viruses goes largely unnoticed. Honeybee colony collapse is noticed. But, despite the fact that facts are facts and the fact that facts about viral microRNAs and nutrient-dependent microRNAs have replaced theories, theorists prefer their ridiculous theories.

Perhaps honeybee colony collapse has nothing to do with their nutrient-dependent pheromone-controlled reproduction. Perhaps Greg Bear was wrong when he claimed that “Networks from beehives to brains solve problems through the exchange and the selective cancellation and modification of signals. Species and organisms in ecosystems live and die like signals in a network.”

Perhaps evolutionary theorists like Masatoshi Nei are correct and “…genomic conservation and constraint-breaking mutation is the ultimate source of all biological innovations and the enormous amount of biodiversity in this world.” Mutation-Driven Evolution (p. 199).

Is there a model for that?

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society