Receptor-mediated biological cause and effect


Nature (supplement) Vol. 486, No. 7403 (). Produced with support from Ajinomoto Co., Inc.

“Taste is central to our being, but this vital sense is only now becoming clear at the biological level. Scientists have identified the receptors that respond to the five basic stimuli of sweet, sour, bitter, salty and umami (savoury), and are now exploring how the brain interprets them. Nature Outlook Taste reports the latest findings from the front lines of flavour.”


Here are links to the two articles from this supplement that I found most useful.


My comment:
Taken together, these two open-access articles from the supplement offer a concise and reasonably accurate overview of the receptor-mediated events that are required for adaptive evolution. After reading 4 pages, it would be difficult for anyone who is vaguely familiar with biologically based cause and effect to attribute the required ecological, social, neurogenic, and cognitive niche construction of adaptive evolution to anything other than the epigenetic effects of olfactory/pheromonal input. There is, however, some misleading information on the role of random mutations. Evolutionary theorists can cling to that.

Unfortunately, the concision did not allow details of the evolved pathway in mammals that links food odors and pheromones directly to behavior via changes in intracellular signaling and stochastic gene expression in the hormone-secreting neurons of the medial preoptic area of the hypothalamus (e.g., in brain tissue). This neurogenic niche controls the development of every other neuronal system that is subsequently linked to behavior. For those details, you will need to read 7 more pages (with 3 pages of references). See, for example: Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

Nevertheless, reading only the 4 pages from the Nature supplement may advance the most vocal and errant of evolutionary theorists to a level of understanding about the importance of receptor-mediated events. This could lead further, perhaps even to an understanding of how animal models and model organisms are used to detail the adaptive evolution of behavior from microbes to man.

Anyone who can’t understand (e.g.,after reading 4 pages) why I focus on receptor-mediated events that cause adaptive evolution should remain silent to avoid letting others know how ignorant they are when it comes to the basic principles of biology and levels of biological organization required to link sensory cause to the adaptive evolution of human behavior.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society