Pheromones make sense of theoretical mutations nonsense

Sci Transl Med 3 April 2013: Vol. 5, Issue 179, p. 179ec57 Sci. Transl. Med.
DOI: 10.1126/scitranslmed.3006205
  • Editors’ Choice


Making Sense of Missense Mutations

Benjamin M. Neale

Genetic variation that is deleterious is on average younger than neutral variation.

Article excerpt: “…the age of a variant may help to identify that subset of genetic variation that has an impact on human disease.”

My comment: This age-variant approach is consistent with reports on the recent origin of most human protein-coding variants. For example, “Even though new genetic variants arise through mutation in each generation, most are present only in a small proportion of individuals because they have slightly negative effects on fitness.” This explains why mutations are not known to contribute to adaptive evolution.

For contrast, it is now clearer that the thermodynamics of epigenetically effected chromatin remodeling is manifested in organism-level thermoregulation and nutrient-dependent pheromone-controlled reproduction, which obviously contributes to adaptive evolution that occurs via ecological, social, neurogenic, and socio-cognitive niche construction. This fact brings evolutionary theory forward in the context of Darwin’s “Conditions of Existence,” which are established before natural or sexual selection can occur. We now know that Darwin’s conditions of existence are nutrient-dependent and pheromone-controlled in species from microbes to man.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society