Pheromones and longevity in worms (and flies)

Scent of Opposite Sex Shortens Lives of Flies and Worms

by Ed Yong

Excerpt: “More seriously, she notes that it’s still not clear if human pheromones even exist. Mice clearly do use pheromones, however, so the next step would be to see if mice can influence the pace of aging in the opposite sex, without ever actually mating. “The experiments could be done, but they’re tricky,” she says.”

My comment: The next step is for academically irresponsible researchers to acknowledge what experimental evidence has already repeatedly shown about food odors, pheromones and longevity. For example, it is perfectly clear that human pheromones exist.

1) Food odors associated with nutrition determine what mice and humans eat (Mori & Sakano, 2011).

2) Experimental evidence also shows that what mice and humans eat is metabolized to species-specific chemicals that control the physiology of reproduction (see for review: Kohl, 2013).

3) Nutrient-dependent pheromone-controlled reproduction in mammals occurs via biophysically constrained molecular mechanisms, which are conserved in species from microbes to man (see for review Facciotti, 2013).

4) Food odors and pheromones alter one signaling pathway in yeasts (Schmidt, 2013).

5) “The mechanism by which one signaling pathway regulates a second provides insight into how cells integrate multiple stimuli to produce a coordinated response.” (Schmidt, 2013)

6) That fact can be compared to the fact that food odors and pheromones alter one signaling pathway in mice and humans to produce a coordinated response (Boehm et al., 2005)

After a brief review of what is already known, cruel experiments could be done to determine if food odors associated with nutrient stress can influence the pace of aging before the animals die of starvation. But what would those experiments prove?  It is obvious that animals cannot live very long without food, no matter how much they appear to like the food odors.  It should be equally obvious that mammalian pheromones influence the pace of aging in mice and humans.

Someone should stop the cruel experiments before people like Brunet start them. There is no need to compare data from experiments with food odors to prove there is social stress associated with not mating when potent pheromones direct the same molecular mechanisms of species survival.  People like Brunet should simply accept that fact that social stress associated with pheromones and nutrient stress associated with food odors reduce the lifespan in every species, not just in mice. How could that not be the case in humans?

Does experimental evidence show that the molecular mechanism of our existence are different from other species? Is it not perfectly clear that in mice and humans the nutrient-dependent physiology of reproduction is pheromone-controlled like it is in every other species on this planet?


Excerpt from Kohl (2013) “In the mouse model, the diet of the mice determines their nutrient-dependent pheromone production and social interactions with other mice. The mouse model also reveals something that was not revealed in the context of dogs and wolves (Axelsson et al., 2013; Lord, 2013). The aversive human body odor associated with fish odor syndrome can be epigenetically controlled by reducing dietary choline intake. It can also be controlled through antibiotic use (citations in Li et al., 2013). This may be important in the context of chemical ecology and epigenetic effects of genetically predisposed nutrient-dependent pheromone-controlled human interactions (Martin et al., 2010; Preti & Leyden, 2010).”

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society