Pheromones, GnRH, and brain development

Effects of peripubertal gonadotropin-releasing hormone agonist on brain development in sheep—A magnetic resonance imaging study exemplifies some of the latest research on molecular mechanisms of adaptive evolution. It also links the latest research to the central focus of my model of nutrient-dependent pheromone-controlled adaptive evolution. The link is via epigenetic effects of food odors and pheromones on gonadotropin-releasing hormone (GnRH).

GnRH is the biological core of mammalian reproductive sexual behavior. Nuruddin et al.,  may be the first in several years to put GnRH in its proper place, which is upstream from everything else involved in behavioral development. They write:

“GnRH is a decapeptide neurohormone that plays a key role in the reproductive axis, ultimately modulating therelease of gonadal steroid hormones. Its receptor (GnRHR) has been found in various brain regions, including the frontal cortex, the olfactory bulb and the limbic system (Albertson et al., 2008; Skinner et al., 2009; Chu et al., 2010; Rosati et al., 2011; Schang et al., 2011). Importantly, not all of these brain regions have roles in the control of reproductive function, suggesting that GnRH is involved in other processes and,as such, may modulate sex differences in emotional processing and cognitive functions.”

In the context above, you may think in terms of GnRH-dependent ecological, social, neurogenic, and socio-cognitive niche construction in mammals. When others realize it is GnRH that controls androgen secretion, like testosterone secretion, and controls oxytocin secretion as well as estrogen secretion, they may also begin to realize why attempts to link hormones to behavior without first linking sensory input to GnRH and other hormones is a ridiculous waste of time.

Those attempts lead to horrid misrepresentations of cause and effect in the context ofDarwinian natural selection. Selection is for nutrients that metabolize to pheromones that control reproduction. There’s a model for that, sans mutations theory! It’s the model I’ve been detailing since its first presentation in 1992.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society