Pheromones and individuality

How individuality develops? Experience leads to the growth of new brain cells.” May 9th, 2013.

News article excerpt: “Our findings show that development itself contributes to differences in adult behavior. This is what many have assumed, but now there is direct neurobiological evidence in support of this claim. Our results suggest that experience influences the aging of the human mind.”

My comment: In our 1996 Hormones and Behavior review article “From Fertilization to Adult Sexual Behavior” we included a section on molecular epigenetics. It established the context of how sensory input from the environment influences the development of our brain and behavior. I’ve since developed a model with more details of how nutrition associated with food odors and socialization associated with pheromones are responsible for the adaptive evolution of our brain and behavior.

Article published in Science: Emergence of Individuality in Genetically Identical Mice

Excerpt: Stochastic gene regulation may lead to individual differences in molecular states, which are further amplified through experience. (iii) Animals might show small changes in the epigenetic state of their genome and may drift epigenetically apart over time, which reflects the cumulative effects of the choices they make in the course of their lives.

My comment:  My specific focus has been on the molecular mechanisms of nutrient-dependent pheromone-controlled stochastic gene regulation:

This model of systems biology represents the conservation of bottom-up organization and top-down activation via:
Nutrient stress-induced and social stress-induced intracellular changes in the microRNA  (miRNA)  /  messenger RNA  (mRNA) balance;
Intermolecular changes in DNA (genes) and alternative splicing;
Non-random experience-dependent stochastic variations in de novo gene expression and biosynthesis of odor receptors;
The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in neurosecretory cells and to miRNA-facilitated learning and memory in the amygdala of the adaptively evolved mammalian brain;
The required reciprocity that links gene expression to behavior that alters gene expression (i.e., reciprocity from genes to behavior and back) in model organisms like the honeybee.”

Thus, my model addresses the missing molecular mechanisms in the context of the Science article’s concluding sentence: “The present paradigm serves as an animal model for addressing the “mystery and controversy” (2) of the nonshared environment, or the ways in which living our lives makes us who we are (29).”

In Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors it is clearer how epigenetic cause and effect eliminate “…the “mystery and controversy” (2) of the nonshared environment…” My model explains how nutrition and socialization during our lives makes us who we are  (e.g., in the context of adaptive evolution).

 

 

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society