Pheromone production: watch what you eat

The article (abstract linked below) exemplifies nutrient-dependent pheromone-controlled adaptive evolution in yeast. Feeding the same species glucose or galactose results in 1.88 million unique transcript isoforms.

In my model, adaptive evolution is thermodynamically controlled by nutrient uptake, which results in organism level thermoregulation due to the metabolism of different nutrients (e.g., carbon sources, like sugars) to pheromones. The pheromones signal species-specific population density in species from microbes to man.

Extensive transcriptional heterogeneity revealed by isoform profiling

Abstract excerpt: Our findings have implications for genome compaction, evolution and phenotypic diversity between single cells.

My comments:

Genetically homogenous populations of yeast cells were grown in two conditions.
1) with glucose as the carbon source;
2) with galactose as the carbon source.

In a genome containing 6,000 open reading frames, the authors report detection of approximately 1.88 million unique transcript isoforms (e.g., 776,874 supported by at least two sequencing reads defined by a unique combination of end sites at single-nucleotide resolution).

If nutrient-dependent adaptive evolution were not pheromone-controlled, accumulated mutations might result in species differences. However, there is no evidence for that! There is also no model for that. Instead, in species from microbes to man, adaptive evolution and species diversity is nutrient-dependent and pheromone-controlled.

Who does not agree that they’ve been fed a story that is not consistent with anything now known about the molecular mechanisms of adaptive evolution? I think that most people have been fed something that has become increasingly distasteful, and the story is scientifically unpalatable (e.g., as feces are to intelligent humans). But many people seem willing to keep feeding the same story to others rather than to examine what happens when different sugars are fed to genetically homogenous populations (i.e., the same species) of yeast.

For contrast, in my model, the different sugars are nutrients that result in differences in pheromone-controlled reproduction (e.g., in species from microbes to man). Perhaps my model will help others to watch what they eat, and stop them from attempting to digest a ridiculous theory or from regurgitating it (i.e., mutations theory).

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society