Perturbed understanding of cause and effect in leukemia

Rare, inherited mutation leaves children susceptible to acute lymphoblastic leukemia

Excerpt: “The change results in the amino acid glycine being substituted for serine at amino acid 183 in the PAX5 protein.”

My comment: Glycine is the “simplest” amino acid; it has only one “achiral” form. It’s substitution in the gonadotropin releasing hormone (GnRH) protein and conserved conformation during what is believed by many people to be approximately 400 million years of adaptive evolution exemplifies the difference between nutrient-dependent pheromone-controlled adaptive evolution and mutation-initiated natural selection.

The difference between nutrient-dependent pheromone-controlled adaptive evolution and mutation-initiated natural selection is that no examples of mutation-initiated natural selection incorporate the physiology of reproduction (e.g., during what supposedly is 400 million years of vertebrate evolution). If there were any examples of mutations that via reproduction remained fixed in the genome for 400 million years, researchers could attempt to determine how the mutation in ALL might have somehow been naturally selected to remain fixed in any portion of any human population, and why it “…affects about 3,000 children nationwide annually…”

Instead, theories that incorporate mutation-driven evolution perturb any understanding of cause and effect by making it seem that substitution of glycine for serine at amino acid 183 in the PAX5 protein can be compared to substitution of glycine for alanine in the GnRH protein.

(I take this perturbed understanding of cause and effect personally since I was involved in specimen collection and the diagnostic testing that confirmed ALL in two children that I continued to perform testing on from 1974-1976).

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society