Passing On Stress

Exposure to an environmental toxin can affect future generations’ ability to handle stressful conditions.

Excerpt: “We are now in the third human generation since the start of the chemical revolution, since humans have been exposed to these kinds of toxins,” David Crews, a zoologist at the University of Texas, at Austin and one of the paper’s lead authors, said in a press release. “This is the animal model of that.”

My comment:

It is now clearer how olfactory/pheromonal input causes beneficial transgenerational epigenetic effects via direct effects of nutrient chemicals on food preferences, and the role that nutrient chemicals play in sexual reproduction via their metabolism to pheromones. From the article: “How an ancestral environmental exposure modifies the germline epigenome and promotes epigenetic transgenerational inheritance is critical in any consideration of tissue function.”  This is the gene, cell, tissue… organ (the brain) organ-system model exemplified in the honeybee model of food odors, pheromones and brain development.

In species from microbes to man receptor-mediated changes caused by nutrient chemicals and pheromones alter intracellular signaling and stochastic gene expression. Thus, olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans. Nutrient chemicals are responsible for the ecological niche, and their metabolism is responsible for the social niche. The ecological and social niche cause the adaptive evolution of the neurogenic niche responsible for invertebrate and vertebrate food choice and mate choice.

I was happy to see the authors express the fact that: “Although no direct epigenetic measurements were made in the current study, the epigenetic model and role of epigenetics in development provides the molecular basis of the observations presented.” Perhaps others will now proceed based on the epigenetic effects of nutrient chemicals and pheromones that have been modeled in species from microbes to man.

Clearly, this is the right model, and it’s time to use it to explain biologically based cause and effect, and to dispense with theories that cannot be modeled using the molecular biology that is common to species from microbes to man.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society