Oxytocin improves social behaviors in a girl with an autistic disorder

Had I been less vocal in my opposition to the “oxytocin does this” approach in autism spectrum disorders, I would not be inclined to post notice of results from an n=1 study. However, when no other hope for treatment is offered, even n=1 may be important to consider, and this is an open access publication.

Long-term oxytocin administration improves social behaviors in a girl with autistic disorder

For contrast, and to avoid implications for false hopes, this study might best be considered with evidence offered in a review article Evolution of neuroarchitecture, multi-level analyses and calibrative reductionism that clearly states: “… the social role of oxytocin did not exist prior to the evolutionary sculpting of the vertebrate brain.” This places the role of oxytocin in, at best, a secondary position behind the role of gonadotropin releasing hormone (GnRH) which is responsible for the evolutionary sculpting of the vertebrate brain. As Kochman (2012) has stated “The discovery of the fact that one decapeptide molecule, among the GnRHs, was constructed perfectly at the beginning of 400 million years evolution and that it is not possible to improve its physiological potency using the any natural amino acid is, in my opinion, important, fascinating and beautiful.”

It is the importance of pheromones and their epigenetic effects on GnRH and the development of social behaviors that has been my focus across the past two decades. But I will not dismiss the potential importance of oxytocin to effective treatment despite the fact that the mechanisms of its effectiveness remain unknown.



About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society