Despite the inaccurate reporting of exeperimental evidence, the link from the nutrient-dependent pheromone-controlled microRNA / messenger RNA balance is becoming clearer. Unfortunately, due to the inaccurate reporting, others may need to take the free course: Epigenetic Control of Gene Expression, before they can begin to understand the scientific progress in cancer research, which is occurring because some researchers have dispensed with the pseudoscientific nonsense of evolutionary theory. See for example: Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing
Excerpt: “…alternative splicing might play a role in uncoupling the expression of clustered miRNAs from each other, which otherwise are generally believed to be co-transcribed and co-expressed.”
My comment: Nutrient uptake leads to miRNA biogenesis, alternative splicings, and RNA-mediated events that are responsible for the differentiation of cell types. Typically, cell type differentiation via amino acid substitutions leads to controlled growth of cells and to increasing organismal complexity. That fact makes it clear that something must go wrong when cell type differentiation is not controlled.
Excerpt: “Whereas intergenic miRs are always regulated by their own promoters, intronic miRs can be either regulated with their host gene or regulated independently of their host gene (28, 29).”
Excerpt: “…it is high expression of miR-3151 that really matters.”
The microRNA/messenger RNA balance is what really matters because it alters nutrient-dependent cell type differentiation via alternative splicings. When evolutionary theorists learn the cause of normal cell type differentiation, which leads to species diversity, they may stop telling people that mutations and natural selection cause evolution. If not, continuing to tout that nonsense will cause others who know that species diversity is nutrient-dependent and pheromone-controlled to claim that evolutionary theorists have prevented scientific progress towards a cure for cancer.