Nutrient dependent pheromone controlled bacterial methylomes

Decoding Bacterial Methylomes

A new technique could soon spur unprecedented insight into the role of bacterial epigenetics in the evolution of pathogen virulence.

May 15, 2013 By

Excerpt: This methylation-laying enzyme resulted in a complete epigenetic makeover, the team learned. The group is still working on characterizing the effects of these epigenetic modifications, but Schadt said that the various pathways that were upregulated and downregulated in the bacterium, including changes in swarming and growth patterns, could have contributed to making it more virulent.

My comment: The effect of the methylation-laying enzyme invites comparison with genes of large effect influence nutrient-dependent pheromone-controlled adaptive evolution in species from microbes to man.

My comment to the Scientist site: Is methylation nutrient-dependent and pheromone-controlled in microbes? If so, this article suggests to me that antibiotic resistence is altered by nutrient-dependent thermodynamically controlled changes in the microRNA/messenger RNA balance. Nutrient-dependent changes in the balance could cause differences in intracellular signaling, internuclear interactions, chromatin remodeling, stochastic gene expression, and changes in seemingly futile cycles of nutrient-dependent de novo protein biosynthesis and degradation.

Successful metabolism of nutrients and protein biosynthesis results in protein degradation to species-specific pheromones that control reproduction by enabling quorum sensing (i.e., the pheromones epigenetically effect organism-level and colony-wide thermoregulation). The ability of one microbial ‘species’ to incorporate nutrient availability and to also withstand nutrient-dependent thermodynamically-controlled increased ‘heat’ is then associated with the species-wide ability to communicate successful competition for nutrients via pheromone production that controls colony growth (and antibiotic resistence in Escherichia coli, for example).

If anyone understands how what I just suggested may explain nutrient-dependent pheromone-controlled adaptive evolution via ecological and social niche construction in microbes, comments are welcome. I do not have the interdisciplinary expertise to move forward with anything more than just a model of cause and effect, and have received no feedback on any aspect of the model or its extension across species from microbes to man in Nutrient-dependent / Pheromone-controlled thermodynamics and thermoregulation.

Perhaps I’ve missed something that is obvious to others.


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society