Nutrient dependent pheromone controlled adaptive evolution (revisited)

FROM THE MAY 2013 ISSUE of Discover

Grandma’s Experiences Leave a Mark on Your Genes

Your ancestors’ lousy childhoods or excellent adventures might change your personality, bequeathing anxiety or resilience by altering the epigenetic expressions of genes in the brain.

By Dan Hurley|Tuesday, April 23, 2013

Excerpt: “A study from Randy Jirtle of Duke University showed that when female mice are fed a diet rich in methyl groups, the fur pigment of subsequent offspring is permanently altered. Without any change to DNA at all, methyl groups could be added or subtracted, and the changes were inherited much like a mutation in a gene.”

My comment: Studies on invertebrates and vertebrates have since shown that adaptive evolution is nutrient-dependent and pheromone-controlled. This links the epigenetic effects of food odors and their metabolism to species specific pheromones to ecological, social, neurogenic, and socio-cognitive niche construction via the molecular mechanisms common to species from microbes to man. The honeybee model organism is one of the best for showing cause and effect. What the queen eats determines her pheromone production and everything involved in the interactions in the colony, including the neuroanatomy of the worker bees’ brains.

Bottom up (nutrient-dependent) and top down (pheromone-control of reproduction) epigenetic effects eliminate from further consideration any theory that posits mutational cause of adaptively evolved phenotypes. Variations are nutrient-dependent and pheromone-controlled, not caused by mutations and runaway selection (–as in selection for what?)

Excerpt: “…natural variations in the amount of licking and grooming received during infancy had a direct effect on how stress hormones, including corticosterone, were expressed in adulthood.”

My comment: The epigentic effect on stress hormones is due to the association of tactile stimulation with nutrient-dependent pheromone-controlled changes in gonadotropin releasing hormone (GnRH) pulse frequency, which alters levels of other hormones during the development of the brain and behavior in mammals.  Cause and effect is olfactory/pheromonal, not tactile. There is no direct effect of tactile stimulation on gene activation in GnRH neurosecretory neurons of the brain. That direct effect is required to link sensory input to differences in development of the brain and to affects on behavior. See for details:


Nutrient-dependent / Pheromone-controlled Adaptive Evolution

Nutrient-dependent / Pheromone-controlled thermodynamics and thermoregulation


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society