Nutrient-dependent non-random personality differences

Personality: The Random Factor

Description: “Benjamin de Bivort, of Harvard, explores what fruit flies can tell us about personality, and also the random differences that develop between individuals and can’t be explained by genetics or environment.”

My comment: The differences are not random. The behavior of the flies exposed to a light stimulus does not address the conserved molecular mechanisms of insect behavioral development, which are nutrient-dependent and pheromone-controlled. For example, the complex wiring of the brain begins in insect larvae. See Nutrient-Sensing Neurons

Excerpt: “…Léopold’s group has found a path from food stimulus to behavior that is faster than predicted.”

My comment: The nutrient-dependent behavior is linked to ingestion of amino acids and a change in three dopamine-secreting neurons. In my model, nutrient-dependent amino acid substitutions stabilize cell type differentiation in the dopaminergic neurons and all other cell types.  That means the adult behavioral response to light reflects changes in the diet of the larvae, which are associated with feedback that epigenetically may effect the amino acid substitutions during life cycle transistions of organisms. Those changes result in transgenerational epigenetic inheritance of morphological and behavioral phenotypes during the development of offspring.

That fact links the ability of nutrient-sensing larvae to adult behavior via conserved molecular mechanisms of amino acid dependent alternative splicings of pre-mRNA, which link the epigenetic landscape to the physical landscape of DNA in the organized genomes of all species.

See also: Mechanism explains complex brain wiring

Conclusion: “These results indicate for the first time the significance of why different sets of the same protein variations can occur in one neuron and it could explain mechanistically how this contributes to the complex wiring in our brain.

Clinical impact

Although this research was done with fruit flies, it also provides new insights that help explain the wiring and complex interactions of the human brain and shine a new light on neurological development disorders such as autism. Thorough knowledge of nerve cell creation and their neural interactions is considered essential knowledge for the future possibility of using stem cell therapy as standard treatment for certain nervous system disorders.”

Journal article excerpt: “The Dscam1 gene uses combinatorial alternative splicing to generate tens of thousands of different receptor isoforms…”

My comment: 

The link from the experience-dependent de novo creation of olfactory receptor genes via alternative splicings of pre-mRNA to nutrient-sensing neurons in insect larvae  suggests the different receptor-mediated behavioral responses of immature and mature organisms are not random and that they are nutrient-dependent and pheromone-controlled.

In my model, food odors associated with nutrient uptake prompt the combinatorial alternative splicings that generate different receptor isoforms, which enable seemingly futile cycles of thermodynamically-regulated protein biosynthesis and degradation that facilitate organism-level thermoregulation in ever-changing ecologies. Ecological adaptations are not manifested in data indirectly associated with visual input, because chemical ecology is the driving force behind ecological adaptations. That does not justify referring to the ecological adaptations as if they resulted from “random” changes.

See for example: Nutrient-dependent / Pheromone-controlled thermodynamics and thermoregulation and my video representation of how non-random personality differences arise.

The ability of flies and humans to detect amino acid concentrations in food throughout their life cycle transitions matches the development of the brain to personalities that are most likely to exemplify ecological adaptations in the absence of mutations or other factors that perturb protein folding — like nutrient-stress and social stress that alter hormone-organized and hormone-activated behaviors in vertbrates and invertebrates. Biophysically-constrained ecological adaptations prevent random differences in personality from achieving species-wide fixation in any species.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society