Null model of speciation and brain genes

Permanent changes in brain genes may not be so permanent after all

In the mouse model of Rett syndrome the changes are nutrient-dependent. This links the epigenetic effects of choline to intercellular signaling, amino acid substitutions, and stochastic expression of newly created genes in the mouse-to-human model of nutrient-dependent pheromone-controlled amino acid substitutions, de novo creation of genes and chromosomal rearrangements.

I used the mouse-to-human model as an example with other examples of ecological adaptations that refute the theory of mutation-driven evolution. My model shows that mutation-initiated natural selection is not biologically plausible or ecologically valid because mutations perturb the protein folding required for increased organismal complexity.

See also: Chromosomal speciation revisited: rearranging theory with pieces of evidence

“Dobzhansky [8] and Muller [9], partially preceded by Bateson [3,7,10] proposed that hybrid sterility and inviability are caused by incompatible alleles alternatively fixed in two previously isolated populations (BDM model). The BDM model is so straightforward that it became the null model of speciation [7] and except for a few strong proponents (notably [1,2]) chromosomal speciation was largely neglected.”

With no experimental evidence whatsoever, a proposal became accepted as a model of speciation because the model was straightforward. Biological Laws were excluded. Darwin’s ‘conditions of life’ were excluded. The physiology of reproduction was excluded. Ecological factors were excluded.

I realize why it’s been so difficult for people to understand my model. It includes too many things that were excluded in the null model of speciation, which they accepted because it was so straightforward.

If I eliminated biologically-based cause and effect from my model, it would be equally straightforward.

It would not be a model of ecological adaptations. It would be nonsense akin to the straightforward null model of speciation (i.e., mutation-driven evolution).


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society