MiRNAs methylation and ecological adaptation sans mutations

MiRNAs methylation and ecological adaptation sans mutations

 Our 2003 Molecular and Cellular Biology paper …opened the mechanistic ‘black box’ of the developmental origins of adult disease susceptibility, and firmly placed the word, epigenetics, in the vernacular of this research field.”  — Randy Jirtle (2009)

Our 1996 Hormones and Behavior paper included a section on molecular epigenetics with evidence that attested to the involvement of epigenetics in the context of olfactory/pheromonal input and the developmental origins of hormone-organized and hormone-activated adult sexual behavior. — James V. Kohl (2014)

Our model was extended to invertebrates in 2000 and to the life history transitions of honeybees in 2005. The model now links the experience-dependent RNA-mediated induction of olfactory receptor gene expression from nutrient-dependent pheromone-controlled ecological adaptations to the creation of species biodiversity in species from microbes to man via conserved molecular mechanisms, which also are linked to perturbed protein folding and the developmental origins of disease. For example see 1, 2, & 3 below with my comments.

1) Odor memories regulate olfactory receptor expression in the sensory periphery. “…olfactory receptor expression is experience-dependent and modulated by scent conditioning…”

Scent conditioning of olfactory receptor (OR) expression  is clearly linked from invertebrates to vertebrates via nutrient uptake in:

2) A Cluster of Olfactory Receptor Genes Linked to Frugivory in Bats.

The authors addressed the experimental “… evidence for ecological niche specialization linked to the evolution of the OR gene repertoire across all major clades of eutherian mammals.”

Taken together with this report:

3)  Large Numbers of Novel miRNAs Originate from DNA Transposons and Are Coincident with a Large Species Radiation in Bats,

these articles conclusively link the epigenetic landscape of invertebrates to the physical landscape of DNA in the organized genomes of invertebrates and vertebrates via the nutrient-dependent assembly of “…functional miRNAs…” that “…influenced the diversification of Vespertilionidae [mammals].”

Thus, the link from food odors to miRNAs and to protein folding required for the de novo creation of OR genes in invertebrates and vertebrates is perfectly clear in the context of conserved molecular mechanisms that link the biophysically constrained nutrient-dependent pheromone-controlled physiology of reproduction to species diversity in species from microbes to man.

Academically irresponsible suppression of accurate representations that detail biophysically-constrained biologically-based cause and effect may continue to delay scientific progress, which might otherwise be made via use of a model that links ecological variation from atoms to ecosystems. Clearly, those who Dobzhansky (1964) labeled ‘bird watchers’ and ‘butterfly collectors’ will continue to tout their pseudoscientific nonsense.

However, they can now be categorized as modern-day antagonists who are still living in an era of ignorance. They continue to ignore the basic principles of biology and levels of biological organization required to link the sensory environment directly to behavior.  That leaves them to tout theories about mutation-initiated natural selection or mutation-driven evolution, which gained popularity despite the lack of experimental evidence to support them.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society