MicroRNAs, calcium, and a clear path to genetic variation (sans mutations)

Study provides strongest clues to date for causes of schizophrenia

It is important for me to note that this study focuses on the fact that “Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.” As in other works that link common genetic variation to differences in typical and atypical behavior, the focus has changed during the past decade from mutation-driven evolution (e.g., a ridiculous gene-centric perspective) to epigenetic effects of the sensory environment on genes (a gene x environment perspective) and on common genetic variation.

The gene x environment approach is more difficult to grasp without some knowledge of conserved molecular mechanisms across species from microbes to man, which is probably why so many people denigrated my works when I wrote about GnRH as THE biological core of mammalian behavior. How can anyone possibly grasp the concept of a “biological core” outside the context of nutrient-dependent pheromone-controlled adaptive evolution? Obviously, they must first dispense with ridiculous theories of mutation-driven evolution and focus on common genetic variation associated with sensory input. Duh!

“We now have a clear and obvious path to getting a fairly complete understanding of the genetic part of schizophrenia. That wouldn’t have been possible five years ago.” — Patrick Sullivan

It would have been possible, beginning about ten years ago, if researchers were better informed about the role of the microRNA/messenger RNA balance in adaptive evolution. By 2005, it was perfectly clear to some researchers: The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution.

In my model, the calcium channel pathway and the “micro-RNA 137” pathway are linked via the nutrient-dependent pheromone-controlled typical and atypical changes in neuronal development that result from epigenetic effects of sensory input on the microRNA/messenger RNA balance. Calcium intake is expected to alter the microRNA/messenger RNA balance. Positive epigenetic effects would benefit the thermodynamics of intercellular signaling, intranuclear interactions, stochastic gene expression, de novo creation of olfactory receptor genes, and organism-level thermoregulation. Negative epigenetic effects of calcium or of other nutrients would be limited by nutrient-dependent pheromone-controlled adaptive evolution.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society