Metabolism, fixation, health or neurodegerative disorder

Citation: Lorbeck M, Pirooznia K, Sarthi J, Zhu X, Elefant F (2011) Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism. PLoS ONE 6(4): e18412. doi:10.1371/journal.pone.0018412
Citation: Lorbeck M, Pirooznia K, Sarthi J, Zhu X, Elefant F (2011) Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism. PLoS ONE 6(4): e18412. doi:10.1371/journal.pone.0018412

“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.”

Microarray Analysis Uncovers a Role for Tip60 in Nervous System Function and General Metabolism

My comment: The article links a nutrient-dependent amino acid substitution via changes in metabolism to cell type differentiation, multicellularity, and brain development in Drosophila. It suggests the substitution is fixed by the model organism’s pheromone-controlled physiology of reproduction.

Excerpt: “…specific deregulation of histone H4 lysine 12 (H4K12) acetylation that corresponds with the misregulation of hippocampal gene expression profiles associated with learning and memory…” in the mouse model.

My comment: The mouse model links nutrient-dependent pheromone-controlled amino acid substitutions and their fixation to cell type differentiation from disruptions to neurodegenerative diseases, such as Alzheimer‘s.

That fact explains more than 18 years of delays in scientific progress towards understanding neurodegenerative diseases. The delays have been caused by the pseudoscientific nonsense of evolutionary theories. The theories are taught to students who typically begin to believe that mutations and natural selection are the cause of human brain development and neurodegenerative diseases.

Students who would like to someday become serious scientists are overwhelmed by professors who continue to tell them that there is proof of evolution. The students are forced to become pseudoscientists who tout the nonsense they were taught to believe in.

Do you remember what you were taught to believe in when you were taught evolutionary biology? If not, too bad. You’re probably a victim of academia who is suffering from cognitive decline attributed to evolutionary theory. If you can remember to do so, try to save your children and grandchildren from a similar fate. Tell them, “Don’t trust pseudoscientists who can’t describe a biologically-based evolutionary event!” Genome Dynamics Events (GDE) involve RNA-directed DNA methylation and RNA-mediated amino acid substitutions that typically stabilize DNA in healthy organisms.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society