Memory of repression and memory of behavior

H3K27me and PRC2 transmit a memory of repression across generations and during development

Reported as:

How epigenetic memory is passed through generations: Sperm and eggs transmit memory of gene repression to embryos


September 18, 2014

Excerpt: “There are dozens of potential epigenetic markers. In studies that document parent-to-child epigenetic inheritance, it’s not clear what’s being passed on, and understanding it molecularly is very complicated. We have a specific example of epigenetic memory that is passed on, and we can see it in the microscope. It’s one piece of the puzzle.”

See: Maleszka et al (2013). They link oxidation of 5Mc to 5hmC from the main pathway that removes methyl tags from the genome to brain-increased levels of 5hmC in gene bodies that correlate with active transcription.

Excerpt: “Within the neuronal function-related genes, gain of 5hmC is accompanied by loss of H3K27me3…”

Taken together with what is known about nutrient-dependent pheromone-controlled cell type differentiation via amino acid substitutions in the honeybee and other model organisms, a model of RNA-mediated cause and effect suggests learning and memory of food odors and species-specific pheromones links transgenerational epigenetic inheritance via the molecular mechanisms that transmit a ‘memory of repression,’ which can be linked to behavior.

The link from conserved molecular mechanisms to transgenerational epigenetic inheritance of behavior appears to occur in the context of the systems complexity of nutrient-dependent changes in the microRNA/messenger RNA balance and the overwhelming influence of all epigenetic effects on cell type differentiation in all cells of all individuals of all organisms (i.e., of all genera). It is now clearer that control of cell type differentiation occurs via the combination of epigenetic effects on the development of morphological phenotypes and on the development of behavioral phenotypes during life history transitions via amino acid substitutions that stabilize DNA in organized genomes via nutrient-dependent pheromone-controlled ecological adaptations to nutrient availability. See also: Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society