Mathematical model: microRNA and epigenetic regulation

September 21, 2014 James V. Kohl Adaptations, Animals, Diseases & Disorders, Ecology, Model Organisms, RNA, Variations 1

Hypothesis & Theory ARTICLE

Front. Genet. | doi: 10.3389/fgene.2014.00345

Interplay of microRNA and epigenetic regulation in the human regulatory network.

Excerpt: “…a detailed model of the epigenetic interaction and its relations with the cellular environment would be required, and this is still an open issue (24).”

My comment: Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

Conclusion:  “Minimally, this model can be compared to any other factual representations of epigenesis and epistasis for determination of the best scientific ‘fit’.”

The model starts with nutrient-uptake and odor-induced de novo creation of receptors that allow nutrients to enter the cell. It links nutrient-dependent changes in the microRNA/messenger RNA balance to the production of species-specific pheromones that control the physiology of reproduction in species from microbes to man.

The conserved molecular mechanisms of amino acid substitutions that stabilize DNA in organized genomes have since been linked to chromosomal rearrangements common in the context of ecological variation that leads to nutrient-dependent pheromone-controlled ecological adaptations all cells of all individuals of all organisms.

If there is a model of evolutionary events linked to biologically-based increasing organismal complexity, it has not been mentioned so that it could be compared to this model of RNA-mediated events. If someone is concealing their model of biologically-based events and evolution, it may never be compared to the conserved molecular mechanisms that appear to result in ecological speciation, outside the context of mutations, natural selection, and the evolution of biodiversity.

Summary: The issue of a detailed model may remain open if only due to the fear my model has instilled among evolutionary theorists who appear to have realized they have not modeled evolution in the context of nutrient-dependent evolutionary events. Kudos to those who have provided a mathematical model that also challenges the approach of population geneticist who invented neo-Darwinism and defined it in terms of DNA-mediated events associated with the pathology of perturbed protein folding, not biodiversity.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society