Male pheromones and mental development

Study finds males may contribute to offspring’s mental development before pregnancy


female mice exposed to male pheromones gave birth to infants with greater mental ability.

“This is the first study to show that pheromone exposure exerts an influence across generations in mammals,” said Sachiko Koyama…


Previously, scientists regarded pheromones as limited to the world of insects.

That is nonsense. A series of published works includes this one, which was co-authored by a Nobel Laureate: Feedback loops link odor and pheromone signaling with reproduction

The first review to link the RNA-mediated nutrient-dependent pheromone-controlled physiology of reproduction via metabolic networks and genetic networks to cell type differentiation in the context of transgenerational epigenetic effects was From Fertilization to Adult Sexual Behavior. The importance of RNA-mediated amino acid substitutions to pheromone-controlled biodiversity was subsequently detailed in Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

The mouse to human model of biologically-based cause and effect was addressed in the context of my review, which was inspired by the ridiculous claims Richard L. Doty made in: The Great Pheromone Myth


Two additional recent reports link substitution of the amino acid alanine for the amino acid valine (Grossman et al., 2013) to nutrient-dependent pheromone-controlled adaptive evolution. The alanine substitution for valine does not appear to be under any selection pressure in mice. The cause-and-effect relationship was established in mice by comparing the effects of the alanine, which is under selection pressure in humans, via its substitution for valine in mice (Kamberov et al., 2013).

A subscription is required to read: Cross-generational impact of a male murine pheromone 2-sec-butyl-4,5-dihydrothiazole in female mice. See also: Chemical identification of MHC-influenced volatile compounds in mouse urine. I: Quantitative Proportions of Major Chemosignals

My comment: MHC-influenced chemosignals are mammalian pheromones, no matter what they have been called in past publications by this group’s senior scientist, or by human pheromone-deniers like “Dick” Doty. If the nutrient-dependent production of species-specific pheromones did not exert an influence on the mental ability of mammals, the ability to link the conserved molecular mechanisms of RNA-mediated cell type differentiation to the physiology of reproduction in all genera would be wasted on theorists who refuse to believe anything that does not require links from mutations to the evolution of biodiversity.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society