Is schizophrenia due to a gene of large effect?

Single gene might explain dramatic differences among people with schizophrenia

“…dramatic differences seen among patients with schizophrenia may be explained by a single gene that regulates a group of other schizophrenia risk genes.”

My model details how the epigenetic tweaking of immense gene networks by nutrients, which is controlled by the metabolism of nutrients to pheromones, causes the development of physical diseases and mental disorders. This article focuses on a particular version of the microRNA-137 gene (or MIR137) instead of microRNA /messenger RNA homeostasis.

Many people seem unable to grasp the concept of microRNA /messenger RNA homeostasis. Is the problem due to what’s taught about the role of random mutations in runaway selection for mutations? Was anyone taught anything about the epigenetic effects of nutrient stress and social stress on the microRNA / messenger RNA balance, which is essential to the concept of biologically based adaptive evolution?

Did anyone ever ask how random mutations result in anything that’s adaptive in the context of the requirements for ecological, social, neurogenic, and socio-cognitive niche construction? Is there evidence that sex differences are somehow involved in a random mutation results in expression of a particular version of the microRNA-137 gene at different times in males compared to females? If so, we could compare evidence that people think supports random mutations theory to the biological facts of rapid regulatory evolution via the de novo emergence of other microRNAs that are essential for the development of the brain and behavior in the human lineage.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society