Human Pheromones: Epigenetic Effects on Hormones and Their Affects on Behavior

Until now, behavioral epigenetics needed to connect all its levels of analysis and provide “… at least one slam-dunk demonstration of all the links in a chain from behavior to neural activity to gene expression and back out again.” When I learned that others thought this demonstration still was needed, I brought my 1992 model current by incorporating the latest perspectives from neuroscience.  One month after the 2012 annual meeting of the Society for Neuroscience, my detailed model now explains how chemical ecology drives adaptive evolution via 1) ecological niche construction, 2) social niche construction, 3) neurogenic niche construction, and 4) socio-cognitive niche construction in accord with my previously published work: see (Kohl, 2012).

I used my updated 1992 model to exemplify the effects of olfactory/pheromonal conditioning. The model now shows that food odors and pheromones alter genetically predisposed, nutrient chemical-dependent, hormone-driven mammalian behavior and choices for pheromones that control reproduction via their effects on luteinizing hormone (Kohl, unpublished). For example, clink on the link below to view my poster presentation from November 9, 2012. It represents two decades of neuroscientific progress.

Human Pheromones: Epigenetic Effects of Odors and Their Affects on Behavior

This poster was submitted to the F1000 poster site on Tuesday 11/13/12, and receipt of the submission was confirmed by “Alla” in an email response to me on 11/16/12, which states:

Hi James, Your poster submission is currently being processed. Your poster will appear on the F1000 Posters website very soon. Regards, Alla


As is indicated in the poster text (provided at the link above): This model of systems biology represents the conservation of bottom-up organization and top-down activation via:
1. Nutrient-dependent stress-induced and social stress-induced intracellular changes in the homeostatic balance of microRNA(miRNA) and messenger RNA (mRNA);
2. Intermolecular changes in DNA (genes);
3. Non-random experience-dependent stochastic variations in de novo gene expression for odor receptors;
4. The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in neurosecretory cells of the brain;
5. The required reciprocity that links gene expression to behavior that alters gene expression (i.e., from genes to behavior and back).

Additional support for this model can be found in: Evolution of the human-specific microRNA miR-941, an open access article. Published on

Across species comparisons of epigenetic effects on genetically predisposed nutrient-dependent and hormone-driven invertebrate and vertebrate social and sexual behavior indicate that human pheromones also alter the development of the brain and behavior via the same molecular mechanisms that are responsible for invertebrate foraging and social behaviors exemplified in the honeybee model organism. Obviously, those molecular mechanisms must be conserved across all species for adaptive evolution of the human brain and human behavior to occur (e.g., via properly timed reproductive sexual behavior of mammals).

Note: In mammals, LH secretion is the measurable proxy for genetically predisposed differences in hypothalamic GnRH pulse frequency and amplitude and the downstream effects of GnRH on the HPG and HPA axes that provide feedback to the GnRH neuronal system, which is the central regulator of genetically predisposed nutrient chemical-dependent individual survival and pheromone-dependent species survival. What this means is that LH is the link between sex and the sense of smell, as indicated in the title of my 1992 presentation: Luteinizing Hormone: The link between sex and the sense of smell? The question mark in the title indicated that in 1992 I was not quite sure of what is now perfectly clear due to neuroscientific progress that epigenetically links olfactory/pheromonal input directly to all the links in a chain from behavior to neural activity to gene expression and back out again.

During the past two decades, my model has gone virtually unrecognized by all but a few distinguished colleagues, and the model has been repeatedly attacked by those who have not distinguished themselves via any efforts to make neuroscientific progress.  The antagonism is to be expected, but I now expect it to end with discussion of whatever I have missed that should be included in the model, or whatever other model anyone think better represents the conservation of the molecular biology of adaptive evolution across species from microbes to man.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society