Human pheromones and the epigenetic effects of isolation

Neglected Babies Develop Less Myelin

By Edyta Zielinska

Mice raised in isolation from their mothers developed cognitive deficits similar to those of babies raised in orphanages where physical contact is infrequent.

Excerpt: Earlier studies had shown that human children raised in isolation or abusive conditions had less white matter in their prefrontal cortex—the part of the brain involved in memory, decision making, and social interactions.

My comment: Doesn’t lowering stress promote the development of white matter via what would otherwise be a negative effect of cortisol suppression on the development and function of the adaptively evolved mammalian hypothalamic gonadotropin releasing hormone (GnRH) neurogenic niche, which is responsible for nutrient chemical-dependent and pheromone-dependent brain development? That was a rhetorical question.

GnRH modulates luteinizing hormone (LH), and a quick glance through the extant literature on neuroendocrine and neuroimmune system function in mammals would show how both GnRH and LH are clearly involved in development of myelination of white matter and differences in gray matter. Stress, for example, negatively impacts both the neuroendocrine and neuroimmune system, which are modulated by GnRH.

What a quick glance would not show is how the epigenetic effects of nutrient chemicals and pheromones cause adaptive evolution and the development of the mammalian hypothalamic GnRH neurogenic niche. For that, you have to look back at the ecological and social niche construction that precedes neurogenic and cognitive niche construction. Across the continuum of ecological, social, neurogenic, and cognitive niche construction we have the conservation of GnRH and diversification of its receptor.

Kochman 2012 had this to say: “The discovery of the fact that one decapeptide molecule, among the GnRHs, was constructed perfectly at the beginning of 400 million years evolution and that it is not possible to improve its physiological potency using the any natural amino acid is, in my opinion, important, fascinating and beautiful.”

The fascinating role of GnRH is central to my model of how nutrient chemicals and pheromones cause adaptive evolution via their effects on LH. The abysmal lack of knowledge of current molecular biology that links the epigenetic effects of nutrient chemicals and pheromones directly to the secretion of hypothalamic GnRH in humans, and to LH secretion and myelination in mammals via exposure to odors and pheromones that are important to brain development, seems destined to delay the realization that human brain development is as dependent on pheromones as it is on nutrient chemicals.

These results extend the requirement for mammalian pheromone-dependent myelination to human infants raised with minimal social contact. The absence of social odors (the pheromones) shows up in behavior caused by their otherwise “normal” epigenetic effects.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society