How could antibiotics alleviate symptoms of schizophrenia?

Chance discovery of link between acne drug and psychosis may unlock secrets of mental illness

Excerpt: “Scientists believe that schizophrenia and other mental illnesses including depression and Alzheimer’s disease may result from inflammatory processes in the brain. Minocycline has anti-inflammatory and neuroprotective effects which they believe could account for the positive findings.”

My comment:

See, for example: Peripheral neuropathy associated with fluoroquinolones. Cohen JS. Ann Pharmacother. 2001 Dec;35(12):1540-7.

I think the most likely cause of the peripheral neuropathy is antibiotic use that kills the bacteria harboring the viruses responsible for maintenance of the peripheral nervous system via their effects on the immune system.

Until we know more about pharmacogenomics, we are left with a problem that is already more than a decade old, which is just now being linked to the possibility of beneficial (or more detrimental) effects and affects. Why, when the effects of antibiotics on the peripheral nervous system have been known, are we just now learning about their effects on the brain and behavior?

There are some obvious correlates with effects of stress-associated odors on immune system function in mice, and an insect model that links nutrient chemicals and social odors to immune system function and the primary emotional functions of affective processing associated with the gene, cell, tissue, organ, organ-system pathway and with food acquisition. This is the foundation for secondary-process learning and memory mechanisms. These genetically predisposed neurophysiological mechanisms are common to species from insects to mammals, and they  interface with our tertiary-process cognitive-thoughtful functions and behavior (Kohl, in press). Perhaps then, the problem is one of pattern recognition. And if we continue to ignore models that link olfactory/pheromonal input to immune system function and the neuroendocrinology of behavior, progress may be delayed with regard to the treatment of psychoses, which include those manifested with loss of olfactory acuity and specificity in age-related disorders, including Alzheimer’s disease.


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society