GnRH molecules link brain and immunity

Dual Function Molecules for Brain and Immunity by Jon Lieff (9/29/13)

Excerpt: “…what has not been appreciated until recently is that many signals, pattern recognition receptors, and a large number of proteins have a dual function in both the immune and nervous systems.”

My comment: “The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences” is a 57-page award-winning book chapter/journal article available as an archived author’s copy.

The model that is detailed in the published work details what may be the earliest appreciation expressed for links between olfactory and immune systems. For example, we introduced nutrient-dependent pheromone-controlled adaptive evolution in the context of a mammalian model of epigenetic effects on gondadotropin releasing hormone (GnRH) via alternative splicings in our 1996 Hormones and Behavior review article. Co-author Teresa Binstock then further developed “An immune hypothesis of sexual orientation” and published it after Elekonich and Robinson (2000) extended our 1996 model of immune system-linked hormone-organized and hormone-activated behavior to insects.

In mammals, GnRH links the olfactory and immune systems to nutrient-dependent pheromone-controlled adaptive evolution of the human brain via ecological, social, neurogenic and socio-cognitive niche construction The conserved molecular mechanisms of niche construction in species from microbes to man are exemplified in many model organisms.

What we now see in the context of recent developments that point towards the immune and nervous systems being the same system, appears to be a reiteration of what Lewis Thomas once said: “The act of smelling something, anything, is remarkably like the act of thinking.

In that same article, it is noteworthy that Lewis Thomas also said:”I should think we might fairly gauge the future of biological science, centuries ahead by estimating the time it will take to reach a complete comprehensive understanding of odor. It may not seem a profound enough problem to dominate all the life sciences, but it contains, piece by piece, all the mysteries.” — as cited in The Scent of Eros: Mysteries of Odor in Human Sexuality.

In his excellent blog posts,  Dr. Lieff has mentioned pheromones twice. However, in the context of linking the immune system and nervous system or realizing that they may be one in the same, the role of pheromones in self versus non-self recognition must rapidly be brought forward. It has, after all been quite clear since 1996, that the epigenetic effects of pheromones link them to GnRH, the immune system, brain development and behavior. Fortunately, Dr.Lieff may clarify for others the biologically based cause and effect that he perceives. But he can not further clarify biologically based cause and effect without providing more information on the role of pheromones in species from microbes to man.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society