Excerpt: …”what is consistent and what we show in our study are the signalling pathways, and this indicates that the same systems (glutamatergic and innate immunity) are probably important to understanding the disorder…”
Predicting the diagnosis of autism spectrum disorder using gene pathway analysis
Excerpt (from the full text of the Molecular Psychiatry article): “While SNPs differ across ethnic groups, our pathway approach identified cellular processes common to ASD across ethnicities.”
My comment:
It’s more productive to study similarities in signaling pathways than differences in genes, races, or species. This is not a novel approach. I modeled the similarities across species from microbes to man to show how differences in nutrient chemicals; their metabolism to pheromones; and their epigenetic effects on intracellular signaling and stochastic gene expression are critical to the understanding of behavioral development.
While waiting for others to examine the similarities in signaling pathways that alter social behavior during its development, we will continue to see the devastating affects of ASDs that must first examined from the perspective of those who understand the consistency of molecular biology in all species that have adaptively evolved.
All individuals require nutrient chemicals and pheromones control their social and sexual behavior. In people there is an evolved gene, cell, tissue, organ, organ system pathway that is important to understanding ASDs and other behaviors. As with any link to behavior, however, researchers must start with sensory input that epigenetically alters intracellular signaling and stochastic gene expression to understand similarities in typical and atypical development.
