Genetic test predicts autism risk

Genetic Test Predicts Autism Risk With High Degree of Accuracy Pam Harrison September 19, 2012

Excerpt:  …”what is consistent and what we show in our study are the signalling pathways, and this indicates that the same systems (glutamatergic and innate immunity) are probably important to understanding the disorder…”

Predicting the diagnosis of autism spectrum disorder using gene pathway analysis

Excerpt (from the full text of the Molecular Psychiatry article): “While SNPs differ across ethnic groups, our pathway approach identified cellular processes common to ASD across ethnicities.”
 
My comment:
It’s more productive to study similarities in signaling pathways than differences in genes, races, or species. This is not a novel approach. I modeled the similarities across species from microbes to man to show how differences in nutrient chemicals; their metabolism to pheromones; and their epigenetic effects on intracellular signaling and stochastic gene expression are critical to the understanding of behavioral development.

While waiting for others to examine the similarities in signaling pathways that alter social behavior during its development, we will continue to see the devastating affects of ASDs that must first examined from the perspective of those who understand the consistency of molecular biology in all species that have adaptively evolved.

All individuals require nutrient chemicals and pheromones control their social and sexual behavior. In people there is an evolved gene, cell, tissue, organ, organ system pathway that is important to understanding ASDs and other behaviors. As with any link to behavior, however, researchers must start with sensory input that epigenetically alters intracellular signaling and stochastic gene expression to understand similarities in typical and atypical development.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society