Exploding genomes and chromosomal rearrangements via RNA-mediated events

Gibbon genome and the fast karyotype evolution of small apes

This is an open access article reported as:

Gibbon genome sequence deepens understanding of primates rapid chromosomal rearrangements

Excerpt: The number of in the gibbons is remarkable, Rogers said. “It is like the genome just exploded and then was put back together,” he said. “Up until recently, it has been impossible to determine how one human chromosome could be aligned to any gibbon chromosome because there are so many rearrangements.”

My comment: Now that researchers have determined how so many chromosomal rearrangements can rapidly occur outside the context of mutations, they can link the genome of gibbons to the human genome via the following sequence of events:

1) nutrient-dependent changes in the

2) microRNA/messenger RNA balance,

3) alternative splicings of pre-mRNA, and

4) RNA-mediated events that link

5) amino acids substitutions to their fixation when they stabilize the DNA in organized genomes of species.

The nutrient-dependent chromosomal rearrangements can then be linked to the RNA-mediated stability of DNA in species from microbes to man via the conserved molecular mechanisms of reproduction isolation due to chromosomal rearrangement and species diversity due to the metabolism of nutrients to species-specific pheromones. which control the physiology of reproduction in species from microbes to man. Thus the conserved molecular mechanisms of RNA-mediated events have again eliminated any further consideration of mutations and natural selection in the evolution of biodiversity.

Until an evolutionary event is described, theorists may continue to invent and define their theories in terms that link mutated DNA to biodiversity and increasing organismal complexity that ‘just happens’ to somehow occur in explosions of chromosomal rearrangements like those that supposedly occurred during the Cambrian explosion. However, the fact that these explosions are nutrient-dependent and pheromone-controlled may mean that biodiversity arises in much less time that might otherwise be predicted in the context of pseudoscientific nonsense of population genetics and neo-Darwinism.

Note also, however, that Genome-wide DNA rearrangements are most exaggerated in ciliates, particularly in the model organism Oxytricha trifallax, which programs not only DNA deletion, but also total reorganization, through RNA-mediated events (Fang et al., 2012; Nowacki et al., 2008).

See the report here on that fact about the conserved molecular mechanisms of RNA-mediated events for comparison to unknown evolutionary events: In one of nature’s innovations, a single cell smashes and rebuilds its own genome

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society