Dr. Darwin at the Bedside It’s time for evolutionary medicine to fully inform clinical research and patient care. By Robert Perlman | October 1, 2013
Excerpt: “Natural selection adjusted how humans use energy and other resources throughout our life cycles in ways that optimized the reproductive fitness of our evolutionary ancestors.”
My comment: NATURAL SELECTION FOR WHAT? Adaptive evolution is clearly nutrient-dependent and nutrients metabolize to species-specific pheromones that control the physiology of reproduction in species from microbes to man via epigenetic effects on conserved molecular mechanisms. Before anything was known by Darwin about genetics, and long before anything was known about epigenetics, Darwin himself tried to tell others that ‘conditions of life’ must be met before natural selection could be considered.
His ‘conditions of life’ are nutrient-dependent and pheromone-controlled. What does that tell you must be natrually selected, and why hasn’t anyone answered that question with the obvious answer: FOOD!
Nutrient stress and social stress act via the same pathway in all mammals. It’s the gonadotropin releasing hormone (GnRH) neuronal system that links the epigenetic effects of glucose and pheromones to all other downstream effects associated with feedback loops that link the epigenetic ‘landscape’ to the physical landscape of DNA in the organized genomes of vertebrates and invertebrates.
Evolutionary medicine should have long ago looked at the cortical computing that must occur in the hormone-secreting “dendrons” of the GnRH neuronal system. Instead, we have a report that dendrites somehow transmit important information from the visual system between neurons — as if that information had any direct effect whatsoever on the hormones that affect behavior.