Epigenetics and the inner voice

Cells Listen to Their Inner Voice

Excerpt: Similar dynamics may occur in the natural setting, resulting from signaling networks built around the same core secrete-and-sense regulatory motif.”

My comment Submitted on Thu, 02/06/2014 – 22:32 and published on Mon, 02/10/2014 – 16:49:

That fact was detailed in “Signaling Crosstalk: Integrating Nutrient Availability and Sex.”

The author noted that: “The mechanism by which one signaling pathway regulates a second provides insight into how cells integrate multiple stimuli to produce a coordinated response.”

In mammals, that signaling pathway is exemplified by the gonadotropin releasing hormone (GnRH) neuronal system. It links food odors and social odors called pheromones from the epigenetic landscape to the physical landscape of DNA via subtle changes in GnRH pulse frequency and amplitude.

The molecular epigenetics of biologically-based cause and effect appear to be conserved in species from microbes to man. This new evidence adds substantial weight to a model of nutrient-dependent pheromone-controlled ecological adaptations.

That model infuriates some evolutionary theorists because it refutes mutation-initiated natural selection. It makes obvious the fact that 1) natural selection is for nutrients, and 2) the nutrients metabolize to species-specific pheromones, which control the physiology of reproduction.

Mutations perturb the protein folding that is required for increased organismal complexity to arise from nutrient-dependent pheromone-controlled amino acid substitutions that stabilize protein folding in the context of ecological, social, neurogenic, and socio-cognitive niche construction.

To my knowledge no experimental evidence links mutations to de novo creation of genes and chromosomal rearrangements or to niche construction, which is why biological plausibility and ecological validity favor a model of nutrient-dependent pheromone-controlled adaptations to ever-changing epigenetic landscapes in all species.




About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society