Epigenetics and metabolism converge with pheromone production

Science 11 January 2013: Vol. 339 no. 6116 pp. 148-150 DOI: 10.1126/science.1233423

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When Metabolism and Epigenetics Converge by Paolo Sassone-Corsi

Excerpt: “Environmental inputs such as nutrition can modulate cell metabolism, and critical links between metabolism and epigenetic control—now widely thought to include chromatin remodeling, histone modifications, DNA methylation, and microRNA pathways (1)—are beginning to emerge (2, 3).”

Conclusion: “The presence of metabolite “niches” within specific chromatin subdomains has been proposed (2) and is conceptually intriguing when placed in parallel with the idea of nuclear subcompartments and transcription “hubs” (16). As connections between epigenetics and metabolism emerge, it may be possible to consider new pharmacological interventions for a variety of pathological conditions.”

My comment to the Science site: In my model, the bottom-up epigenetic effects of nutrient chemicals on intracellular signaling and stochastic gene expression are controlled by the metabolism of the nutrient chemicals to pheromones that epigenetically effect intracellular signaling and stochastic gene expression from the top down.  Simply put, the microRNA / messenger RNA balance that is required for homeostasis and epistasis is nutrient chemical-dependent and pheromone-controlled by environmental effects on gene expression, which lead to genetically predisposed behaviors and back to gene expression via sensory input (e.g., food or pheromones). Since adaptive evolution is obviously a function of nutrient chemical-dependent pheromone-controlled reproduction in species from microbes to man, it is somewhat surprising that the epigenetic effects of pheromones on intracellular signaling and stochastic gene expression have been virtually ignored beyond their contribution to quorum sensing in microbes.

Indeed, Richard Doty went so far as to publish a 2010 book that argued against the obvious fact that mammalian pheromones exist. Shall we attribute to him the inability to see that metabolism and epigenetics converge with food odors and the metabolism of nutrient chemicals to pheromones that act on precisely the same molecular mechanisms of adaptive evolution found in species from microbes to man? And if not for him and other human pheromone-deniers, does the bell toll for me?

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society