Epigenetic effects on chromatin and regulatation of gene expression (in Archaea?)

    • The Scientist News & Opinion 12/10/12

Conserved Chromatin? Re: R. Ammar et al., “Chromatin is an ancient innovation conserved between Archaea and Eukarya,” eLife, 1:e00078, 2012.

Excerpt: “If the primary role for chromatin is not packaging, it might instead be to regulate gene expression,” Nislow said.

My comment:

At the advent of sexual reproduction, a type of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans. This epigenetic imprinting is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes. Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans. That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

The new information on conserved chromatin suggests it makes sense to move backwards across the continuum of adaptive evolution and attempt to determine whether the conservation of chromatin between Archeea and Eukarya is nutrient chemical-dependent and pheromone-controlled, since this appears to be the case via the epigenetic effects of nutrient chemicals and pheromones on all life (e.g., as we know it).  Nevertheless, the bottom-up epigenetic effects of nutrient chemicals on speciation that are concurrently controlled by the top-down epigenetic effects of pheromones on reproduction challenges those who might rather attempt to-explain away the conserved molecular biology of adaptive evolution via random mutations theory.  I don’t see how any existing theory could explain cause and effect exemplified by complex systems biology in the simplest of organisms with their “ancient innovation” of conserved chromatin. Is there a model of adaptively evolved Natural Selection and Sexual Selection for that?

See also:  The activity-dependent histone variant H2BE modulates the life span of olfactory neurons
Stephen W Santoro and Catherine Dulac (2012) “These findings uncover a novel mechanism by which the sensory experience of a neuron is recorded within its chromatin to affect its transcriptional program and longevity.”

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society