Epigenetic effects of viruses on cellular homeostasis

Viruses Affect Cell Reprogramming

Viral vectors used to carry transcription factors that de-differentiate cells into a stem-cell-like state are themselves a key factor in efficient reprogramming.

By Sabrina Richards | October 25, 2012


Excerpt: “It’s not the first time epigenetic marks have been fingered as key players in cellular reprogramming, and it’s probably not the last.”

My Comment: In two science fiction novels: “Darwin’s Children” (2003) and  “Darwin’s Radio” (1999), Greg Bear incorporated the concept of viral-induced epigenetic changes in cellular reprogramming into stories about the evolution of a new species of human.

In “Origin of group identity: viruses, addiction and cooperation” (2009),  L.P. Villarreal incorporated the scientific facts that supported Bear’s stories into the concept of adaptive evolution (e.g., via ecological, social, neurogenic, and socio-cognitive niche construction).

It has since become clearer that the epigenetic effects of virus-driven changes in intracellular signaling and stochastic gene expression (e.g., due to microRNA/mRNA – driven intermolecular changes) are associated with nutrient chemical-dependent cell survival and pheromone-controlled reproduction in species from microbes to man.

If, as suggested in this article, virus-driven inflammation pushes chromatin toward a plastic state that enables malignant transformation, the control of cellular and organism-wide homeostasis by the epigenetic effects that inhibit viral replication (e.g., proper nutrition and social stress inhibition), might be the best approach to prevent our evolution to another species, or our diet-driven and social stress-driven extinction.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society